Masahiro Yaguchi
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Explore the profile of Masahiro Yaguchi including associated specialties, affiliations and a list of published articles.
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10
Citations
179
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Recent Articles
1.
Inagaki T, Sato Y, Ito J, Takaki M, Okuno Y, Yaguchi M, et al.
Front Microbiol
. 2024 Jun;
15:1426311.
PMID: 38846570
[This corrects the article DOI: 10.3389/fmicb.2020.575255.].
2.
Sato Y, Yaguchi M, Okuno Y, Ishimaru H, Sagou K, Ozaki S, et al.
Cell Commun Signal
. 2022 Jun;
20(1):95.
PMID: 35729616
Background: Viruses must adapt to the environment of their host cells to establish infection and persist. Diverse mammalian cells, including virus-infected cells, release extracellular vesicles such as exosomes containing proteins...
3.
Inagaki T, Sato Y, Ito J, Takaki M, Okuno Y, Yaguchi M, et al.
Front Microbiol
. 2021 Feb;
11:575255.
PMID: 33613459
Viral infection induces dynamic changes in transcriptional profiles. Virus-induced and antiviral responses are intertwined during the infection. Epstein-Barr virus (EBV) is a human gammaherpesvirus that provides a model of herpesvirus...
4.
Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, et al.
EMBO Mol Med
. 2018 May;
10(6).
PMID: 29769258
The modulation of pre-mRNA splicing is proposed as an attractive anti-neoplastic strategy, especially for the cancers that exhibit aberrant pre-mRNA splicing. Here, we discovered that T-025 functions as an orally...
5.
Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong T, et al.
Bioorg Med Chem
. 2018 Apr;
26(9):2452-2465.
PMID: 29669694
We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and growth suppression of cancer cells. High-throughput screening and medicinal chemistry efforts...
6.
Niida A, Sasaki S, Yonemori K, Sameshima T, Yaguchi M, Asami T, et al.
Bioorg Med Chem Lett
. 2017 May;
27(12):2757-2761.
PMID: 28457754
A structure-activity relationship study of a K-Ras(G12D) selective inhibitory cyclic peptide, KRpep-2d was performed. Alanine scanning of KRpep-2d focusing on the cyclic moiety showed that Leu, Ile, and Asp are...
7.
Sakamoto K, Kamada Y, Sameshima T, Yaguchi M, Niida A, Sasaki S, et al.
Biochem Biophys Res Commun
. 2017 Feb;
484(3):605-611.
PMID: 28153726
Amino-acid mutations of Gly (e.g. G12D, G12V, G12C) of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras), the most promising drug target in cancer therapy, are major growth drivers in...
8.
Yaguchi M, Shibata S, Satomi Y, Hirayama M, Adachi R, Asano Y, et al.
Biochem Biophys Res Commun
. 2017 Jan;
484(3):493-500.
PMID: 28108287
Metabolic reprogramming is an essential hallmark of neoplasia. Therefore, targeting cancer metabolism, including lipid synthesis, has attracted much interest in recent years. Serine palmitoyltransferase (SPT) plays a key role in...
9.
Nakayama A, Takagi S, Yusa T, Yaguchi M, Hayashi A, Tamura T, et al.
J Cancer
. 2013 Aug;
4(7):557-65.
PMID: 23983820
Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR)...
10.
Yaguchi M, Wada Y, Toh Y, Iguchi H, Kono A, Matsusue K, et al.
Biochim Biophys Acta
. 2006 Feb;
1732(1-3):8-14.
PMID: 16445996
The metastasis-associated gene 1 (mta1) was identified initially in rat highly metastatic cancer cell lines and found to be a component of the nucleosome remodeling and histone deacetylase (NuRD) complex....