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Marzia Perluigi

Explore the profile of Marzia Perluigi including associated specialties, affiliations and a list of published articles. Areas
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Articles 135
Citations 4386
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Recent Articles
21.
Zuliani I, Lanzillotta C, Tramutola A, Francioso A, Pagnotta S, Barone E, et al.
Neurotherapeutics . 2020 Dec; 18(1):340-363. PMID: 33258073
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer's disease (AD),...
22.
Bouzidi A, Magnifico M, Paiardini A, Macone A, Boumis G, Giardina G, et al.
Cell Death Dis . 2020 Nov; 11(11):1012. PMID: 33243973
Nutrient utilization and reshaping of metabolism in cancer cells is a well-known driver of malignant transformation. Less clear is the influence of the local microenvironment on metastasis formation and choice...
23.
Lanzillotta C, Greco V, Valentini D, Villani A, Folgiero V, Caforio M, et al.
Antioxidants (Basel) . 2020 Nov; 9(11). PMID: 33187268
Down syndrome (DS) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans, which results from the triplication of chromosome 21. To search for...
24.
Genovese I, Giamogante F, Barazzuol L, Battista T, Fiorillo A, Vicario M, et al.
Cell Death Dis . 2020 Oct; 11(10):861. PMID: 33060591
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), and targeting...
25.
Perluigi M, Tramutola A, Pagnotta S, Barone E, Butterfield D
Antioxidants (Basel) . 2020 Aug; 9(9). PMID: 32839417
Down syndrome (DS) is the most common genetic cause of intellectual disability that is associated with an increased risk to develop early-onset Alzheimer-like dementia (AD). The brain neuropathological features include...
26.
Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, et al.
Prog Neurobiol . 2020 Aug; 196:101892. PMID: 32795489
A major challenge in neurobiology is the identification of the mechanisms by which protein misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant protein conformers aggregate into pathological...
27.
Dierssen M, Fructuoso M, Martinez de Lagran M, Perluigi M, Barone E
Front Neurosci . 2020 Aug; 14:670. PMID: 32733190
Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy...
28.
Lanzillotta C, Zuliani I, Vasavda C, Snyder S, Paul B, Perluigi M, et al.
Antioxidants (Basel) . 2020 Jul; 9(8). PMID: 32727065
Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of...
29.
Lloret A, Monllor P, Fuchsberger T, Giraldo E, Perluigi M, Vina J
Free Radic Res . 2020 Jul; 54(6):442-454. PMID: 32686528
RCAN1 is an inhibitor of the phosphatase calcineurin, which is involved in the regulation of oxidative stress and apoptosis, among other important cell processes. Here we have used RCAN1 deficient...
30.
Protto V, Tramutola A, Fabiani M, Marcocci M, Napoletani G, Iavarone F, et al.
Microorganisms . 2020 Jul; 8(7). PMID: 32610629
Compelling evidence supports the role of oxidative stress in Alzheimer's disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a neurotropic virus that establishes a lifelong latent infection in the trigeminal...