Mary Marfori
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Explore the profile of Mary Marfori including associated specialties, affiliations and a list of published articles.
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10
Citations
417
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Recent Articles
1.
Rona G, Marfori M, Borsos M, Scheer I, Takacs E, Toth J, et al.
Acta Crystallogr D Biol Crystallogr
. 2013 Dec;
69(Pt 12):2495-505.
PMID: 24311590
Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is essential for genomic integrity, has...
2.
Marfori M, Lonhienne T, Forwood J, Kobe B
Traffic
. 2012 Jan;
13(4):532-48.
PMID: 22248489
Classical nuclear localization signals (cNLSs), comprising one (monopartite cNLSs) or two clusters of basic residues connected by a 10-12 residue linker (bipartite cNLSs), are recognized by the nuclear import factor...
3.
Marfori M, Kobe B, Forwood J
J Biol Chem
. 2011 Aug;
286(41):35643-35649.
PMID: 21849495
Acyl-coenzyme A (acyl-CoA) thioesterases play a crucial role in the metabolism of activated fatty acids, coenzyme A, and other metabolic precursor molecules including arachidonic acid and palmitic acid. These enzymes...
4.
Marfori M, Mynott A, Ellis J, Mehdi A, Saunders N, Curmi P, et al.
Biochim Biophys Acta
. 2010 Oct;
1813(9):1562-77.
PMID: 20977914
Although proteins are translated on cytoplasmic ribosomes, many of these proteins play essential roles in the nucleus, mediating key cellular processes including but not limited to DNA replication and repair...
5.
Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures
Forwood J, Lange A, Zachariae U, Marfori M, Preast C, Grubmuller H, et al.
Structure
. 2010 Sep;
18(9):1171-83.
PMID: 20826343
The structure of solenoid proteins facilitates a higher degree of flexibility than most folded proteins. In importin-β, a nuclear import factor built from 19 tandem HEAT repeats, flexibility plays a...
6.
Lonhienne T, Forwood J, Marfori M, Robin G, Kobe B, Carroll B
J Biol Chem
. 2009 Jun;
284(34):22549-58.
PMID: 19549784
Ran-GTP interacts strongly with importin-beta, and this interaction promotes the release of the importin-alpha-nuclear localization signal cargo from importin-beta. Ran-GDP also interacts with importin-beta, but this interaction is 4 orders...
7.
Roman N, Kirkby B, Marfori M, Kobe B, Forwood J
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2009 May;
65(Pt 6):625-8.
PMID: 19478448
The transport of macromolecules across the nuclear envelope is an essential eukaryotic process that enables proteins such as transcription factors, polymerases and histones to gain access to the genetic material...
8.
Kobe B, Guncar G, Buchholz R, Huber T, Maco B, Cowieson N, et al.
Biochem Soc Trans
. 2008 Nov;
36(Pt 6):1438-41.
PMID: 19021571
Crystallography is commonly used for studying the structures of protein-protein complexes. However, a crystal structure does not define a unique protein-protein interface, and distinguishing a 'biological interface' from 'crystal contacts'...
9.
Forwood J, Lonhienne T, Marfori M, Robin G, Meng W, Guncar G, et al.
J Mol Biol
. 2008 Aug;
383(4):772-82.
PMID: 18708071
The asymmetric distribution of the nucleotide-bound state of Ran across the nuclear envelope is crucial for determining the directionality of nuclear transport. In the nucleus, Ran is primarily in the...
10.
Forwood J, Thakur A, Guncar G, Marfori M, Mouradov D, Meng W, et al.
Proc Natl Acad Sci U S A
. 2007 Jun;
104(25):10382-7.
PMID: 17563367
Acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoA to free fatty acid and CoA and thereby regulate lipid metabolism and cellular signaling. We present a comprehensive structural and functional...