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Murray Stewart

Explore the profile of Murray Stewart including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 106
Citations 4332
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Cell Biology
Top 10 Co-Authors
Thomas M Roberts
Eugene Valkov
Anita H Corbett
Shintaro Aibara
Ed Hurt
David Neuhaus
Jade K Forwood
Divyang Jani
Fred Yang
Richard P Grant
Published In
J Biol Chem
Nucleic Acids Res
J Mol Biol
EMBO J
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
To flex or not to flex: oesophageal soft food bolus obstruction in the modern age
Moen C, Tailor H, Hammond S, Hay B, Peedika N, McMurran A, et al.
J Laryngol Otol . 2024 Apr; 138(9):957-960. PMID: 38686530
Background: Oesophageal soft food bolus obstruction is a common presentation to emergency departments. Often these patients are given medication with little evidence of efficacy. Although many cases self-resolve, some require...
2.
A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome
Badolato R, Alsina L, Azar A, Bertrand Y, Bolyard A, Dale D, et al.
Blood . 2024 Apr; 144(1):35-45. PMID: 38643510
We investigated efficacy and safety of mavorixafor, an oral CXCR4 antagonist, in participants with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency caused by CXCR4 gain-of-function variants. This...
3.
Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
Donnelly C, Stewart M, Roby J, Sundaramoorthy V, Forwood J
Viruses . 2024 Jan; 16(1):33. PMID: 38229694
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein...
4.
Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide
Wabitsch M, Farooqi S, Fluck C, Bratina N, Mallya U, Stewart M, et al.
J Endocr Soc . 2022 May; 6(6):bvac057. PMID: 35528826
Context: Rare homozygous or biallelic variants in , , and can disrupt signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia and severe early-onset obesity. In pivotal Phase 3...
5.
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
Munasinghe T, Edwards M, Tsimbalyuk S, Vogel O, Smith K, Stewart M, et al.
Nat Commun . 2022 Mar; 13(1):1604. PMID: 35338144
The MERS coronavirus (MERS-CoV) is a highly pathogenic, emerging virus that produces accessory proteins to antagonize the host innate immune response. The MERS-CoV ORF4b protein has been shown to bind...
6.
Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm
Stewart M
Int J Mol Sci . 2022 Mar; 23(5). PMID: 35269721
Although the separation of transcription and translation, mediated by the nuclear envelope, is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic compartments needs to be semipermeable...
7.
Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency
Kuhnen P, Wabitsch M, von Schnurbein J, Chirila C, Mallya U, Callahan P, et al.
Orphanet J Rare Dis . 2022 Feb; 17(1):38. PMID: 35123544
Introduction: Individuals with proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiency are young and experience severe obesity, hyperphagia, and comorbidities, which can impair quality of life (QOL). Methods: Two pivotal Phase...
8.
Helical ordering of envelope-associated proteins and glycoproteins in respiratory syncytial virus
Conley M, Short J, Burns A, Streetley J, Hutchings J, Bakker S, et al.
EMBO J . 2021 Dec; 41(3):e109728. PMID: 34935163
Human respiratory syncytial virus (RSV) causes severe respiratory illness in children and the elderly. Here, using cryogenic electron microscopy and tomography combined with computational image analysis and three-dimensional reconstruction, we...
9.
Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
Jagga B, Edwards M, Pagin M, Wagstaff K, Aragao D, Roman N, et al.
Nat Commun . 2021 Jan; 12(1):28. PMID: 33397924
SOX (SRY-related HMG-box) transcription factors perform critical functions in development and cell differentiation. These roles depend on precise nuclear trafficking, with mutations in the nuclear targeting regions causing developmental diseases...
10.
Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials
Clement K, van den Akker E, Argente J, Bahm A, Chung W, Connors H, et al.
Lancet Diabetes Endocrinol . 2020 Nov; 8(12):960-970. PMID: 33137293
Background: The melanocortin 4 receptor (MC4R), a component of the leptin-melanocortin pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused by biallelic variants in genes that...