Martina Zafferani
Overview
Explore the profile of Martina Zafferani including associated specialties, affiliations and a list of published articles.
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7
Citations
103
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Recent Articles
1.
Martyr J, Zafferani M, Bailey M, Zorawski M, Montalvan N, Muralidharan D, et al.
bioRxiv
. 2025 Feb;
PMID: 39990451
The potential of therapeutically targeting RNA with small molecules continues to grow yet progress is hindered by difficulties in determining specific mechanisms of action, including impacts on RNA-protein binding. RNA...
2.
Zafferani M, Martyr J, Muralidharan D, Montalvan N, Cai Z, Hargrove A
ACS Chem Biol
. 2022 Aug;
17(9):2437-2447.
PMID: 35984959
The rapidly accelerating characterization of RNA tertiary structures has revealed their pervasiveness and active roles in human diseases. Small molecule-mediated modulation of RNA tertiary structures constitutes an attractive avenue for...
3.
Zafferani M, Muralidharan D, Montalvan N, Hargrove A
RSC Chem Biol
. 2022 Jul;
3(7):905-915.
PMID: 35866161
The exponential increase in the discovery and characterization of RNA tertiary structures has highlighted their active role in a variety of human diseases, yet often their interactome and specific function...
4.
Cai Z, Zafferani M, Akande O, Hargrove A
J Med Chem
. 2022 May;
65(10):7262-7277.
PMID: 35522972
The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by...
5.
Zafferani M, Haddad C, Luo L, Davila-Calderon J, Chiu L, Mugisha C, et al.
Sci Adv
. 2021 Nov;
7(48):eabl6096.
PMID: 34826236
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication...
6.
Zafferani M, Hargrove A
Cell Chem Biol
. 2021 Apr;
28(5):594-609.
PMID: 33823146
Initial successes in developing small molecule ligands for non-coding RNAs have underscored their potential as therapeutic targets. More recently, these successes have been aided by advances in biophysical and structural...
7.
Donlic A, Zafferani M, Padroni G, Puri M, Hargrove A
Nucleic Acids Res
. 2020 Jul;
48(14):7653-7664.
PMID: 32667657
Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive avenue for cancer treatment and a...
8.
Rastogi S, Zhao Z, Barrett S, Shelton S, Zafferani M, Anderson H, et al.
Eur J Med Chem
. 2017 Nov;
143:1-7.
PMID: 29172077
Colchicine analogues in which an azo group is incorporated into a molecule containing the key pharmacophore of colchicine, have found particular utility as switchable tubulin binding chemotherapeutics. Combretastatin is a...