Martin Ungerer
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Explore the profile of Martin Ungerer including associated specialties, affiliations and a list of published articles.
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52
Citations
768
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Recent Articles
21.
Degen H, Borst O, Ziegler M, Mojica Munoz A, Jamasbi J, Walker B, et al.
J Am Heart Assoc
. 2017 Jul;
6(8).
PMID: 28751543
Background: GPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI-Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding...
22.
Mojica Munoz A, Jamasbi J, Uhland K, Degen H, Munch G, Ungerer M, et al.
Thromb Haemost
. 2017 Jun;
117(8):1651-1659.
PMID: 28569920
The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding...
23.
Holthoff H, Li Z, Fassbender J, Reimann A, Adler K, Munch G, et al.
Endocrinology
. 2017 Apr;
158(7):2376-2390.
PMID: 28368444
A model for human Graves disease in mice was used to compare several treatment approaches. The mice received regular adenovirus (Ad) thyroid-stimulating hormone receptor (TSHR) A subunit immunizations (injections every...
24.
Reimann A, Li Z, Goebel S, Fassbender J, Holthoff H, Gawaz M, et al.
Heart Int
. 2016 Dec;
11(1):e10-e16.
PMID: 27924212
Background: Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) remains the only approved medication for acute ischemic stroke, but incurs significant bleeding risks. Therefore, approaches to combine lower doses of...
25.
Jamasbi J, Megens R, Bianchini M, Uhland K, Munch G, Ungerer M, et al.
JACC Basic Transl Sci
. 2016 Oct;
1(3):131-142..
PMID: 27766315
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the...
26.
Ungerer M, Fassbender J, Li Z, Munch G, Holthoff H
Clin Rev Allergy Immunol
. 2016 Jul;
52(2):182-193.
PMID: 27368808
Various approaches have been used to model human Graves' disease in mice, including transfected fibroblasts, and plasmid or adenoviral immunisations with the extracellular A subunit of the human thyrotropin receptor...
27.
Baumgartner C, Brandl J, Munch G, Ungerer M
Prog Biophys Mol Biol
. 2016 Jun;
121(2):131-41.
PMID: 27261072
Animal models of atherosclerosis often present limitations of transferability, since important hallmarks of human disease are not completely reproduced in other species. Rabbits have been used in several approaches: 1)...
28.
Jamasbi J, Megens R, Bianchini M, Munch G, Ungerer M, Faussner A, et al.
J Am Coll Cardiol
. 2015 Jun;
65(22):2404-15.
PMID: 26046734
Background: Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential. Objectives:...
29.
Holthoff H, Goebel S, Li Z, Fassbender J, Reimann A, Zeibig S, et al.
Endocrinology
. 2015 Jan;
156(4):1577-89.
PMID: 25562617
A transient model for human Graves' disease was successfully established in mice using up to 3 immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human TSH receptor (TSHR)...
30.
Bigalke B, Phinikaridou A, Andia M, Cooper M, Schuster A, Schonberger T, et al.
Circ Cardiovasc Imaging
. 2013 Oct;
6(6):957-64.
PMID: 24107491
Background: Plaque erosion leads to exposure of subendothelial collagen, which may be targeted by glycoprotein VI (GPVI). We aimed to detect plaque erosion using (64)Cu-labeled GPVI-Fc (fragment crystallized). Methods And...