Martin Sprick
Overview
Explore the profile of Martin Sprick including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
683
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0
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Recent Articles
1.
Cheytan T, Schneider M, Wurth R, Schwerd-Kleine P, Gutjahr E, Thewes V, et al.
Mol Cancer
. 2025 Mar;
24(1):72.
PMID: 40057730
Metastatic breast cancer remains largely incurable, partly due to our incomplete understanding of its intricate underlying mechanisms. Notably, intercellular communication mediated by small extracellular vesicles and particles (sEVPs) has emerged...
2.
Thiel V, Renders S, Panten J, Dross N, Bauer K, Azorin D, et al.
Nature
. 2025 Feb;
PMID: 39961335
The peripheral nervous system (PNS) orchestrates organ function in health and disease. Most cancers including pancreatic ductal adenocarcinoma (PDAC) are infiltrated by PNS neurons, contributing to the complex tumor microenvironment...
3.
Rieckmann L, Spohn M, Ruff L, Agorku D, Becker L, Borchers A, et al.
Mol Cancer
. 2024 May;
23(1):93.
PMID: 38720314
Background: Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yield...
4.
Bozza M, Green E, Espinet E, De Roia A, Klein C, Vogel V, et al.
Mol Ther Methods Clin Dev
. 2020 May;
17:957-968.
PMID: 32420409
We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating vectors. They represent a unique genetic tool, which...
5.
Buck E, Sprick M, Gaida M, Grullich C, Weber T, Herpel E, et al.
Oncol Lett
. 2019 Mar;
17(4):3890-3898.
PMID: 30881507
Recently, a tumor-autonomous cytochrome P450 (CYP)-3A5-mediated resistance to cancer therapy has been demonstrated in pancreatic ductal adenocarcinoma. Expression of CYP3A5, which is involved in the degradation of irinotecan, has also...
6.
Jabs J, Zickgraf F, Park J, Wagner S, Jiang X, Jechow K, et al.
Mol Syst Biol
. 2017 Nov;
13(11):955.
PMID: 29180611
Cancer drug screening in patient-derived cells holds great promise for personalized oncology and drug discovery but lacks standardization. Whether cells are cultured as conventional monolayer or advanced, matrix-dependent organoid cultures...
7.
Baccelli I, Schneeweiss A, Riethdorf S, Stenzinger A, Schillert A, Vogel V, et al.
Nat Biotechnol
. 2013 Apr;
31(6):539-44.
PMID: 23609047
It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is...
8.
Wachter T, Sprick M, Hausmann D, Kerstan A, McPherson K, Stassi G, et al.
J Biol Chem
. 2004 Oct;
279(51):52824-34.
PMID: 15459191
Human keratinocytes undergo apoptosis following treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via surface-expressed TRAIL receptors 1 and 2. In addition, TRAIL triggers nonapoptotic signaling pathways including activation of...