Martin Sendzik
Overview
Explore the profile of Martin Sendzik including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
284
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0
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Recent Articles
1.
Huang Y, Sendzik M, Zhang J, Gao Z, Sun Y, Wang L, et al.
J Med Chem
. 2022 Mar;
65(7):5317-5333.
PMID: 35352560
Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On...
2.
LaMarche M, Acker M, Argintaru A, Bauer D, Boisclair J, Chan H, et al.
J Med Chem
. 2020 Sep;
63(22):13578-13594.
PMID: 32910655
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role...
3.
Sarver P, Acker M, Bagdanoff J, Chen Z, Chen Y, Chan H, et al.
J Med Chem
. 2019 Mar;
62(7):3781.
PMID: 30900883
No abstract available.
4.
Bagdanoff J, Chen Z, Acker M, Chen Y, Chan H, Dore M, et al.
J Med Chem
. 2019 Mar;
62(7):3780.
PMID: 30900881
No abstract available.
5.
Bagdanoff J, Chen Z, Acker M, Chen Y, Chan H, Dore M, et al.
J Med Chem
. 2019 Jan;
62(4):1781-1792.
PMID: 30688462
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic transformation. SHP2 also participates in the programed cell death pathway...
6.
Sarver P, Acker M, Bagdanoff J, Chen Z, Chen Y, Chan H, et al.
J Med Chem
. 2019 Jan;
62(4):1793-1802.
PMID: 30688459
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the...
7.
Zhao Q, Manning J, Sutton J, Costales A, Sendzik M, Shafer C, et al.
ACS Med Chem Lett
. 2018 Jul;
9(7):746-751.
PMID: 30034612
Mutant isocitrate dehydrogenase 1 (IDH1) is an attractive therapeutic target for the treatment of various cancers such as AML, glioma, and glioblastoma. We have evaluated 3-pyrimidin-4-yl-oxazolidin-2-ones as mutant IDH1 inhibitors...
8.
Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, et al.
ACS Chem Biol
. 2018 Jan;
13(3):647-656.
PMID: 29304282
SHP2 is a cytoplasmic protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell proliferation, differentiation, and survival. Recently, we reported an allosteric mechanism of inhibition that...
9.
Cho Y, Levell J, Liu G, Caferro T, Sutton J, Shafer C, et al.
ACS Med Chem Lett
. 2017 Oct;
8(10):1116-1121.
PMID: 29057061
Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg. Having identified an allosteric, induced pocket of IDH1, we...
10.
Lingel A, Sendzik M, Huang Y, Shultz M, Cantwell J, Dillon M, et al.
J Med Chem
. 2016 Dec;
60(1):415-427.
PMID: 27992714
PRC2 is a multisubunit methyltransferase involved in epigenetic regulation of early embryonic development and cell growth. The catalytic subunit EZH2 methylates primarily lysine 27 of histone H3, leading to chromatin...