Martin J Humphries
Overview
Explore the profile of Martin J Humphries including associated specialties, affiliations and a list of published articles.
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Articles
149
Citations
8019
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Recent Articles
1.
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
Samarzija I, Lukiyanchuk V, Loncaric M, Rac-Justament A, Stojanovic N, Gorodetska I, et al.
Front Cell Dev Biol
. 2024 Aug;
12:1452463.
PMID: 39149513
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145...
2.
Maldonado H, Savage B, Barker H, May U, Vahatupa M, Badiani R, et al.
Nat Commun
. 2024 Jan;
15(1):234.
PMID: 38172142
No abstract available.
3.
Maldonado H, Savage B, Barker H, May U, Vahatupa M, Badiani R, et al.
Nat Commun
. 2023 Dec;
14(1):8069.
PMID: 38057316
CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has inherent ability to promote wound healing: wounds close and re-epithelialise faster...
4.
Khan M, Salomaa S, Jacquemet G, Butt U, Miihkinen M, Deguchi T, et al.
J Cell Sci
. 2023 Oct;
136(19).
PMID: 37823537
No abstract available.
5.
Loncaric M, Stojanovic N, Rac-Justament A, Coopmans K, Majhen D, Humphries J, et al.
Cell Mol Biol Lett
. 2023 Jul;
28(1):56.
PMID: 37460977
Background: Focal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways that control cell proliferation, differentiation, survival and motility. Microtubules...
6.
Pearsall S, Williamson S, Humphrey S, Hughes E, Morgan D, Garcia Marques F, et al.
J Thorac Oncol
. 2023 Jul;
18(10):1362-1385.
PMID: 37455012
Introduction: Vasculogenic mimicry (VM), the process of tumor cell transdifferentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including SCLC....
7.
Acharya B, Fang J, Jeffery E, Chavkin N, Genet G, Vasavada H, et al.
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37197981
Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest lack mechanistic understanding. We previously showed that arterial shear stress up-regulates Cx37 in endothelial cells and activates a Notch/Cx37/p27 signaling...
8.
Satta S, Beal R, Smith R, Luo X, Ferris G, Langford-Smith A, et al.
Cardiovasc Res
. 2023 Feb;
119(9):1869-1882.
PMID: 36804807
Aims: Endothelial erosion of plaques is responsible for ∼30% of acute coronary syndromes (ACS). Smoking is a risk factor for plaque erosion, which most frequently occurs on the upstream surface...
9.
Mana G, Valdembri D, Askari J, Li Z, Caswell P, Zhu C, et al.
Life Sci Alliance
. 2022 Nov;
6(2).
PMID: 36410791
Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. Integrin allosteric changes, clustering, and trafficking cooperate to regulate cell adhesion and motility...
10.
Humphries J, Zha J, Burns J, Askari J, Below C, Chastney M, et al.
Matrix Biol
. 2022 Apr;
110:16-39.
PMID: 35405272
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical...