Martin Haslbeck
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Explore the profile of Martin Haslbeck including associated specialties, affiliations and a list of published articles.
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85
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3383
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Recent Articles
1.
Peters C, Haslbeck M, Buchner J
Trends Biochem Sci
. 2024 Sep;
49(12):1063-1078.
PMID: 39271417
Small heat shock proteins (sHsps) are an important part of the cellular system maintaining protein homeostasis under physiological and stress conditions. As molecular chaperones, they form complexes with different non-native...
2.
Rodina N, Hornung S, Sarkar R, Suladze S, Peters C, Schmid P, et al.
J Am Chem Soc
. 2024 Jul;
146(28):19077-19087.
PMID: 38973199
Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but can contain...
3.
Muhlhofer M, Offensperger F, Reschke S, Wallmann G, Csaba G, Berchtold E, et al.
FEBS Lett
. 2024 Feb;
598(6):635-657.
PMID: 38366111
The response to proteotoxic stresses such as heat shock allows organisms to maintain protein homeostasis under changing environmental conditions. We asked what happens if an organism can no longer react...
4.
Hildenbrand K, Bohnacker S, Menon P, Kerle A, Prodjinotho U, Hartung F, et al.
Sci Adv
. 2023 Oct;
9(43):eadg6874.
PMID: 37878703
Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position in inflammatory and infectious diseases. Each family member consists of an...
5.
Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, et al.
J Mol Biol
. 2023 Oct;
435(23):168300.
PMID: 37805067
Interleukin 12 (IL-12) family cytokines connect the innate and adaptive branches of the immune system and regulate immune responses. A unique characteristic of this family is that each member is...
6.
Strauch A, Rossa B, Kohler F, Haeussler S, Muhlhofer M, Ruhrnossl F, et al.
J Biol Chem
. 2022 Nov;
299(1):102753.
PMID: 36442512
Small Heat shock proteins (sHsps) are a family of molecular chaperones that bind nonnative proteins in an ATP-independent manner. Caenorhabditis elegans encodes 16 different sHsps, among them Hsp17, which is...
7.
Tas K, Volta B, Lindner C, El Bounkari O, Hille K, Tian Y, et al.
Nat Commun
. 2022 Aug;
13(1):5004.
PMID: 36008417
Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide (Aβ) and islet amyloid polypeptide (IAPP),...
8.
Prodjinotho U, Gres V, Henkel F, Lacorcia M, Dandl R, Haslbeck M, et al.
EMBO Rep
. 2022 Mar;
23(5):e54096.
PMID: 35357743
Immunoregulation of inflammatory, infection-triggered processes in the brain constitutes a central mechanism to control devastating disease manifestations such as epilepsy. Observational studies implicate the viability of Taenia solium cysts as...
9.
Muhlhofer M, Peters C, Kriehuber T, Kreuzeder M, Kazman P, Rodina N, et al.
Nat Commun
. 2021 Nov;
12(1):6697.
PMID: 34795272
Hsp26 is a small heat shock protein (sHsp) from S. cerevisiae. Its chaperone activity is activated by oligomer dissociation at heat shock temperatures. Hsp26 contains 9 phosphorylation sites in different...
10.
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane
Sperl L, Ruhrnossl F, Schiller A, Haslbeck M, Hagn F
EMBO J
. 2021 Sep;
40(20):e107159.
PMID: 34523144
Permeabilization of the outer mitochondrial membrane by pore-forming Bcl2 proteins is a crucial step for the induction of apoptosis. Despite a large set of data suggesting global conformational changes within...