Johannes Buchner
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Explore the profile of Johannes Buchner including associated specialties, affiliations and a list of published articles.
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221
Citations
9783
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Recent Articles
1.
Kaduhr L, Mayer K, Schaffrath R, Buchner J, Brinkmann U
FEBS Lett
. 2025 Jan;
PMID: 39825589
The diphthamide modification of eukaryotic translation elongation factor (eEF2) is important for accurate protein synthesis. While the enzymes for diphthamide synthesis are known, coordination of eEF2 synthesis with the diphthamide...
2.
Giannone C, Mess X, He R, Chelazzi M, Mayer A, Bakunts A, et al.
EMBO J
. 2024 Dec;
44(2):505-533.
PMID: 39632981
Polymeric IgM immunoglobulins have high avidity for antigen and complement, and dominate primary antibody responses. They are produced either as assemblies of six µ2L2 subunits (i.e., hexamers), or as pentamers...
3.
Riedl S, Bilgen E, Agam G, Hirvonen V, Jussupow A, Tippl F, et al.
Nat Commun
. 2024 Oct;
15(1):8627.
PMID: 39366960
Hsp90 is a molecular chaperone of central importance for protein homeostasis in the cytosol of eukaryotic cells, with key functional and structural traits conserved from yeast to man. During evolution,...
4.
Peters C, Haslbeck M, Buchner J
Trends Biochem Sci
. 2024 Sep;
49(12):1063-1078.
PMID: 39271417
Small heat shock proteins (sHsps) are an important part of the cellular system maintaining protein homeostasis under physiological and stress conditions. As molecular chaperones, they form complexes with different non-native...
5.
Rodina N, Hornung S, Sarkar R, Suladze S, Peters C, Schmid P, et al.
J Am Chem Soc
. 2024 Jul;
146(28):19077-19087.
PMID: 38973199
Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but can contain...
6.
7.
Rani K, Gotmare A, Maier A, Menghal R, Akhtar N, Fangaria N, et al.
J Biol Chem
. 2024 May;
300(6):107342.
PMID: 38705392
Posttranslational modifications of Hsp90 are known to regulate its in vivo chaperone functions. Here, we demonstrate that the lysine acetylation-deacetylation dynamics of Hsp82 is a major determinant in DNA repair...
8.
Trommer J, Lesniowski F, Buchner J, Svilenov H
Protein Sci
. 2024 Apr;
33(5):e4990.
PMID: 38607241
The antigen-binding sites in conventional antibodies are formed by hypervariable complementarity-determining regions (CDRs) from both heavy chains (HCs) and light chains (LCs). A deviation from this paradigm is found in...
9.
Pasham D, Tombesi F, Sukova P, Zajacek M, Rakshit S, Coughlin E, et al.
Sci Adv
. 2024 Mar;
10(13):eadj8898.
PMID: 38536930
Binaries containing a compact object orbiting a supermassive black hole are thought to be precursors of gravitational wave events, but their identification has been extremely challenging. Here, we report quasi-periodic...
10.
Muhlhofer M, Offensperger F, Reschke S, Wallmann G, Csaba G, Berchtold E, et al.
FEBS Lett
. 2024 Feb;
598(6):635-657.
PMID: 38366111
The response to proteotoxic stresses such as heat shock allows organisms to maintain protein homeostasis under changing environmental conditions. We asked what happens if an organism can no longer react...