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Martin F Wolfson

Explore the profile of Martin F Wolfson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 124
Followers 0
Related Specialties
Biochemistry
Rheumatology
General Medicine
Top 10 Co-Authors
Stanford L Peng
Stacey R Dillon
Katherine E Lewis
Steven D Levin
Mark W Rixon
Sherri Mudri
Lawrence S Evans
Jing Yang
Pamela M Holland
Janhavi G Bhandari
Published In
Arthritis Rheumatol
J Biol Chem
Sci Transl Med
Bioconjug Chem
Nat Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101)
Dillon S, Evans L, Lewis K, Debrot S, Blair T, Mudri S, et al.
Arthritis Rheumatol . 2023 Mar; 75(8):1344-1356. PMID: 36862144
Objective: CD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in T cell activation and adaptive immunity. We undertook this study to characterize in vitro and in...
2.
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases
Evans L, Lewis K, DeMonte D, Bhandari J, Garrett L, Kuijper J, et al.
Arthritis Rheumatol . 2023 Jan; 75(7):1187-1202. PMID: 36705554
Objective: Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple autoimmune diseases, including systemic lupus erythematosus and lupus nephritis. We undertook this study to develop and evaluate a high-affinity...
3.
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
Maurer M, Lewis K, Kuijper J, Ardourel D, Gudgeon C, Chandrasekaran S, et al.
Nat Commun . 2022 Apr; 13(1):1790. PMID: 35379805
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy....
4.
ICOSL plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist
Adom D, Dillon S, Yang J, Liu H, Ramadan A, Kushekhar K, et al.
Sci Transl Med . 2020 Oct; 12(564). PMID: 33028709
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 cell...
5.
Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains
Levin S, Evans L, Bort S, Rickel E, Lewis K, Wu R, et al.
Front Immunol . 2020 Feb; 10:3086. PMID: 32038630
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for...
6.
Identification of 14-3-3zeta by chemical affinity with salicylanilide inhibitors of interleukin-12p40 production
Boyce J, Brown M, Chin W, Fitzner J, Paxton R, Shen M, et al.
Bioconjug Chem . 2008 Sep; 19(9):1775-84. PMID: 18763820
Salicylanilides were found as selective inhibitors of interleukin-12p40 production in stimulated dendritic cells. The conversion of one of these bioactive salicylanilides into a comparably bioactive, chemically labeled derivative was achieved...
7.
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule
Galibert L, Diemer G, Liu Z, Johnson R, Smith J, Walzer T, et al.
J Biol Chem . 2005 Mar; 280(23):21955-64. PMID: 15781451
Dendritic cells (DCs) are a phenotypically and functionally heterogenous population of leukocytes with distinct subsets serving a different set of specialized immune functions. Here we applied an in vitro whole...