Martin Augustin
Overview
Explore the profile of Martin Augustin including associated specialties, affiliations and a list of published articles.
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32
Citations
659
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Recent Articles
11.
Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(7):E1437-E1445.
PMID: 29382749
Dipeptidyl peptidases 8 and 9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology. While the DPP family member DPP4 is extensively...
12.
Dyck B, Branstetter B, Gharbaoui T, Hudson A, Breitenbucher J, Gomez L, et al.
J Med Chem
. 2017 Apr;
60(8):3472-3483.
PMID: 28406621
A series of potent thienotriazolopyrimidinone-based PDE1 inhibitors was discovered. X-ray crystal structures of example compounds from this series in complex with the catalytic domain of PDE1B and PDE10A were determined,...
13.
Vasbinder M, Alimzhanov M, Augustin M, Bebernitz G, Bell K, Chuaqui C, et al.
Bioorg Med Chem Lett
. 2015 Nov;
26(1):60-7.
PMID: 26614408
We have identified a class of azabenzimidazoles as potent and selective JAK1 inhibitors. Investigations into the SAR are presented along with the structural features required to achieve selectivity for JAK1...
14.
Eylenstein R, Weinfurtner D, Hartle S, Strohner R, Bottcher J, Augustin M, et al.
MAbs
. 2015 Sep;
8(1):176-86.
PMID: 26406987
X-ray structure analysis of 4 antibody Fab fragments, each in complex with human granulocyte macrophage colony stimulating factor (GM-CSF), was performed to investigate the changes at the protein-protein binding interface...
15.
Park G, Baek S, Kim J, Lim T, Lee C, Yang H, et al.
Biochem Pharmacol
. 2015 Sep;
98(3):473-83.
PMID: 26341390
While skin aging is a naturally occurring process by senescence, exposure to ultraviolet (UV) radiation accelerates wrinkle formation and sagging of skin. UV induces skin aging by degrading collagen via...
16.
Paricharak S, Klenka T, Augustin M, Patel U, Bender A
J Cheminform
. 2013 Dec;
5(1):49.
PMID: 24330772
Background: 'Phylogenetic trees' are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no...
17.
Vasbinder M, Aquila B, Augustin M, Chen H, Cheung T, Cook D, et al.
J Med Chem
. 2013 Feb;
56(5):1996-2015.
PMID: 23398453
B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. We have discovered a novel class...
18.
Gao Y, Davies S, Augustin M, Woodward A, Patel U, Kovelman R, et al.
Biochem J
. 2013 Feb;
451(2):313-28.
PMID: 23398362
Despite the development of a number of efficacious kinase inhibitors, the strategies for rational design of these compounds have been limited by target promiscuity. In an effort to better understand...
19.
Baek S, Kang N, Popowicz G, Arciniega M, Jung S, Byun S, et al.
J Mol Biol
. 2012 Nov;
425(2):411-23.
PMID: 23142567
c-Jun NH2-terminal kinases (JNKs) and phosphatidylinositol 3-kinase (PI3-K) play critical roles in chronic diseases such as cancer, type II diabetes, and obesity. We describe here the binding of quercetagetin (3,3',4',5,6,7-hydroxyflavone),...
20.
Engel K, Schrock K, Teupser D, Holdt L, Tonjes A, Kern M, et al.
PLoS One
. 2012 Jan;
6(12):e29400.
PMID: 22216272
G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic...