Marko Novinec
Overview
Explore the profile of Marko Novinec including associated specialties, affiliations and a list of published articles.
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40
Citations
476
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Recent Articles
1.
Obaha A, Novinec M
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38069440
This comprehensive review addresses the intricate and multifaceted regulation of peptidase activity in human health and disease, providing a comprehensive investigation that extends well beyond the boundaries of the active...
2.
Geri A, Massai L, Novinec M, Turel I, Messori L
Chempluschem
. 2023 Nov;
89(2):e202300321.
PMID: 37930642
Medicinal gold compounds, a novel class of potential anticancer drugs, are believed to produce their pharmacological effects mainly through direct gold binding to protein targets at the level of solvent...
3.
Strancar V, van Midden K, Krahn D, Morimoto K, Novinec M, Funk C, et al.
iScience
. 2022 Nov;
25(11):105247.
PMID: 36339259
Metacaspases are essential cysteine proteases present in plants, fungi, and protists that are regulated by calcium binding and proteolytic maturation through mechanisms not yet understood. Here, we developed and validated...
4.
Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S
Novinec M, Bembic P, Jankovic M, Kisilak M, Kljun J, Turel I
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012257
Heavy metal ions can disrupt biological functions via multiple molecular mechanisms, including inhibition of enzymes. We investigate the interactions of human papain-like cysteine endopeptidases cathepsins L, K, and S with...
5.
Kladnik J, Dolinar A, Kljun J, Perea D, Grau-Exposito J, Genesca M, et al.
J Enzyme Inhib Med Chem
. 2022 Aug;
37(1):2158-2168.
PMID: 35943189
Zinc pyrithione (), together with its analogues - and ruthenium pyrithione complex , were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed...
6.
Vah L, Medved T, Groselj U, Klemencic M, Podlipnik C, Stefane B, et al.
Molecules
. 2022 Jul;
27(15).
PMID: 35897941
In silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase...
7.
Varda N, Novinec M
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163774
Human dipeptidyl peptidase I (DPPI) belongs to the family of papain-like cysteine peptidases. Its distinctive features are the unique exclusion domain which enables the eponymous activity and homotetramerization of DPPI,...
8.
Zivic Z, Strmsek Z, Novinec M, Lah J, Hadzi S
FASEB J
. 2022 Feb;
36(3):e22199.
PMID: 35157347
Spike trimer plays a key role in SARS-CoV-2 infection and vaccine development. It consists of a globular head and a flexible stalk domain that anchors the protein into the viral...
9.
Gorican T, Ciber L, Petek N, Svete J, Novinec M
Bioorg Chem
. 2021 Aug;
115:105213.
PMID: 34364050
Cathepsins K and S are closely related papain-like cysteine peptidases and potential therapeutic targets for metabolic and inflammatory diseases such as osteoporosis and arthritis. Here we describe the reduction of...
10.
Ulcakar L, Novinec M
Biomolecules
. 2021 Jan;
11(1).
PMID: 33383850
Caffeic acid (CA) and its derivatives caffeic acid phenethyl ester (CAPE) and chlorogenic acid (CGA) are phenolic compounds of plant origin with a wide range of biological activities. Here, we...