Mark R Wade
Overview
Explore the profile of Mark R Wade including associated specialties, affiliations and a list of published articles.
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18
Citations
880
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Recent Articles
1.
Fazakerley D, van Gerwen J, Cooke K, Duan X, Needham E, Diaz-Vegas A, et al.
Nat Commun
. 2023 Feb;
14(1):923.
PMID: 36808134
The failure of metabolic tissues to appropriately respond to insulin ("insulin resistance") is an early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to the adipocyte...
2.
Czyzyk T, Andrews J, Coskun T, Wade M, Hawkins E, Lockwood J, et al.
Am J Physiol Endocrinol Metab
. 2013 May;
305(2):E282-92.
PMID: 23715724
Obesity continues to be a global health problem, and thus it is imperative that new pathways regulating energy balance be identified. Recently, it was reported: (Hayashi K, Cao T, Passmore...
3.
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
Holland W, Miller R, Wang Z, Sun K, Barth B, Bui H, et al.
Nat Med
. 2010 Dec;
17(1):55-63.
PMID: 21186369
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how adiponectin can exert such a variety of beneficial systemic...
4.
Tzavara E, Degroot A, Wade M, Davis R, Nomikos G
Eur Neuropsychopharmacol
. 2009 Jan;
19(3):196-204.
PMID: 19116182
Blockade of the cannabinoid CB1 receptors (CB1R) has been shown to reduce psychostimulant-induced hyperactivity, an effect that we sought to further characterize here. The CB1R antagonist SR141716A dose-dependently decreased d-amphetamine-induced...
5.
Tzavara E, Wade M, Davis R, El Khoury M, Nomikos G
Synapse
. 2008 Sep;
62(12):940-3.
PMID: 18798268
We investigated the participation of the metabotropic glutamate receptor type 5 (mGluR5) in mediating increases in cortical acetylcholine (ACh) efflux elicited by established or putative neuropsychotherapeutic compounds, using in vivo...
6.
Perry K, Falcone J, Fell M, Ryder J, Yu H, Love P, et al.
Neuropharmacology
. 2008 Jul;
55(5):743-54.
PMID: 18602930
Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and...
7.
Gras C, Amilhon B, Lepicard E, Poirel O, Vinatier J, Herbin M, et al.
Nat Neurosci
. 2008 Feb;
11(3):292-300.
PMID: 18278042
Three subtypes of vesicular transporters accumulate glutamate into synaptic vesicles to promote its vesicular release. One of the subtypes, VGLUT3, is expressed in neurons, including cholinergic striatal interneurons, that are...
8.
Wade M, Gurr G, Wratten S
Philos Trans R Soc Lond B Biol Sci
. 2007 Sep;
363(1492):831-47.
PMID: 17761469
Sustainable agricultural practices in conjunction with ecological restoration methods can reduce the detrimental effects of agriculture. The Society for Ecological Restoration International has produced generic guidelines for conceiving, organizing, conducting...
9.
Wade M, Degroot A, Nomikos G
Eur J Pharmacol
. 2006 Oct;
551(1-3):162-7.
PMID: 17030030
Although the involvement of cannabinoids and the endogenous cannabinoid system in the regulation of the hypothalamo-pituitary-adrenal axis in rodents is well documented, the precise role played by the cannabinoid type...
10.
Degroot A, Kofalvi A, Wade M, Davis R, Rodrigues R, Rebola N, et al.
Mol Pharmacol
. 2006 Jul;
70(4):1236-45.
PMID: 16855179
Evidence indicates that blockade of cannabinoid receptors increases acetylcholine (ACh) release in brain cortical regions. Although it is assumed that this type of effect is mediated through CB1 receptor (CB1R)...