Mark Mellett
Overview
Explore the profile of Mark Mellett including associated specialties, affiliations and a list of published articles.
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31
Citations
325
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Recent Articles
1.
Mellett M, Danis J, Meier-Schiesser B
Front Immunol
. 2025 Mar;
16:1568773.
PMID: 40028327
No abstract available.
2.
OSiorain J, Cox S, Payet C, Nally F, He Y, Drewinksi T, et al.
FASEB J
. 2024 Dec;
38(24):e70235.
PMID: 39686706
Macrophages are innate immune cells that orchestrate the process of inflammation, which varies across time of day. This ensures appropriate biological timing of the immune response with the external environment....
3.
Knoch C, Baghin V, Turko P, Winkelbeiner N, Staeger R, Wei K, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273670
Lichen planus (LP) is a highly prevalent inflammatory skin disease. While various clinical subtypes have been defined, detailed comparisons of these variants are lacking. This study aimed to elucidate differences...
4.
Mamaghani S, Penna R, Frei J, Wyss C, Mellett M, Look T, et al.
Cells
. 2024 Aug;
13(15.
PMID: 39120273
Synthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development. Such synthetic mRNA typically contains several...
5.
Abboud E, Chrayteh D, Boussetta N, Dalle H, Malerba M, Wu T, et al.
Nat Commun
. 2024 Aug;
15(1):6718.
PMID: 39112467
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains...
6.
Holzinger T, Frei J, Jarzebska N, Beer H, Kundig T, Pascolo S, et al.
Anticancer Drugs
. 2024 Jul;
35(10):912-921.
PMID: 39012759
Chemotherapies are standard care for most cancer types. Pyrimidine analogs including 5-fluorouracil, cytosine arabinoside, 5-azacytidine, and gemcitabine are effective drugs that are utilized as part of a number of anticancer...
7.
Schmauch E, Severin Y, Xing X, Mangold A, Conrad C, Johannsen P, et al.
Sci Adv
. 2024 Jul;
10(27):eado2365.
PMID: 38959302
Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease with a poorly understood pathogenesis. Through a molecularly driven precision medicine approach and an extensive mechanistic pathway analysis in PRP...
8.
Keller J, O Siorain J, Kundig T, Mellett M
Biochem Soc Trans
. 2024 Jun;
52(4):1591-1604.
PMID: 38940747
Interleukin-36 (IL-36) cytokines are structurally similar to other Interleukin-1 superfamily members and are essential to convey inflammatory responses at epithelial barriers including the skin, lung, and gut. Due to their...
9.
Jarzebska N, Frei J, Mellett M, Kundig T, Pascolo S, Reichmuth A
Methods Mol Biol
. 2024 May;
2786:237-254.
PMID: 38814398
During recent years, RNA therapeutics have begun to make a substantial impact in the clinic, with the approval of the siRNA-based therapeutic Patisiran in 2018, and of the two mRNA...
10.
Frei J, Jarzebska N, Mellett M, Kundig T, Pascolo S, Reichmuth A
Methods Mol Biol
. 2024 May;
2786:205-215.
PMID: 38814396
The recent success of the synthetic mRNA-based anti-COVID-19 vaccines has demonstrated the broad potential of the mRNA platform for applications in medicine, thanks to the combined efforts of a small...