Mark J Koenigsknecht
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Explore the profile of Mark J Koenigsknecht including associated specialties, affiliations and a list of published articles.
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21
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1322
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Recent Articles
1.
Yu A, Koenigsknecht M, Hens B, Baker J, Wen B, Jackson T, et al.
AAPS J
. 2019 Nov;
22(1):3.
PMID: 31712917
Multiple approaches such as mathematical deconvolution and mechanistic oral absorption models have been used to predict in vivo drug dissolution in the gastrointestinal (GI) tract. However, these approaches are often...
2.
Seekatz A, Schnizlein M, Koenigsknecht M, Baker J, Hasler W, Bleske B, et al.
mSphere
. 2019 Mar;
4(2).
PMID: 30867328
Although the microbiota in the proximal gastrointestinal (GI) tract have been implicated in health and disease, much about these microbes remains understudied compared to those in the distal GI tract....
3.
Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, et al.
Mol Pharm
. 2018 Nov;
15(12):5468-5478.
PMID: 30417648
Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available to investigate the impact of GI physiology...
4.
Bermejo M, Paixao P, Hens B, Tsume Y, Koenigsknecht M, Baker J, et al.
Mol Pharm
. 2018 Oct;
15(12):5454-5467.
PMID: 30372084
The goal of this project was to explore and to statistically evaluate the responsible gastrointestinal (GI) factors that are significant factors in explaining the systemic exposure of ibuprofen, between and...
5.
Truax A, Chen L, Tam J, Cheng N, Guo H, Koblansky A, et al.
Cell Host Microbe
. 2018 Sep;
24(3):364-378.e6.
PMID: 30212649
In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but...
6.
Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, et al.
Eur J Pharm Biopharm
. 2018 Jun;
129:162-174.
PMID: 29857136
The goal of this study was to create a mass transport model (MTM) model for gastric emptying and upper gastrointestinal (GI) appearance that can capture the in vivo concentration-time profiles...
7.
Chen L, Wilson J, Koenigsknecht M, Chou W, Montgomery S, Truax A, et al.
Nat Immunol
. 2017 Oct;
18(11):1270.
PMID: 29044233
This corrects the article DOI: 10.1038/ni.3690.
8.
Koenigsknecht M, Baker J, Wen B, Frances A, Zhang H, Yu A, et al.
Mol Pharm
. 2017 Sep;
14(12):4295-4304.
PMID: 28937221
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of...
9.
Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht M, Baker J, et al.
Mol Pharm
. 2017 Jul;
14(12):4281-4294.
PMID: 28737409
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time,...
10.
Chen L, Wilson J, Koenigsknecht M, Chou W, Montgomery S, Truax A, et al.
Nat Immunol
. 2017 Jul;
18(8):951.
PMID: 28722719
No abstract available.