Mark J Ammirati
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Explore the profile of Mark J Ammirati including associated specialties, affiliations and a list of published articles.
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8
Citations
376
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Recent Articles
1.
Liu S, Ammirati M, Song X, Knafels J, Zhang J, Greasley S, et al.
J Biol Chem
. 2012 Feb;
287(17):13598-610.
PMID: 22298776
Human glucokinase (GK) is a principal regulating sensor of plasma glucose levels. Mutations that inactivate GK are linked to diabetes, and mutations that activate it are associated with hypoglycemia. Unique...
2.
Ammirati M, Andrews K, Boyer D, Brodeur A, Danley D, Doran S, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):1991-5.
PMID: 19275964
A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone (5) emerged as a potent (IC(50)...
3.
Wright S, Ammirati M, Andrews K, Brodeur A, Danley D, Doran S, et al.
Bioorg Med Chem Lett
. 2007 Sep;
17(20):5638-42.
PMID: 17822893
A series of pyrrolidine based inhibitors of dipeptidyl peptidase IV were developed from a high throughput screening hit for the treatment of type 2 diabetes. Potency, selectivity, and pharmacokinetic properties...
4.
Vajdos F, Hoth L, Geoghegan K, Simons S, Lemotte P, Danley D, et al.
Protein Sci
. 2007 Apr;
16(5):897-905.
PMID: 17456742
Lasofoxifene is a new and potent selective estrogen receptor modulator (SERM). The structural basis of its interaction with the estrogen receptor has been investigated by crystallographic analysis of its complex...
5.
Cunningham D, Danley D, Geoghegan K, Griffor M, Hawkins J, Subashi T, et al.
Nat Struct Mol Biol
. 2007 Apr;
14(5):413-9.
PMID: 17435765
Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density lipoprotein (LDL) receptor through an undefined mechanism. The structure of human PCSK9 shows the subtilisin-like catalytic site...
6.
Qiu X, Mistry A, Ammirati M, Chrunyk B, Clark R, Cong Y, et al.
Nat Struct Mol Biol
. 2007 Jan;
14(2):106-13.
PMID: 17237796
Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Inhibition of CETP...
7.
Wright S, Ammirati M, Andrews K, Brodeur A, Danley D, Doran S, et al.
J Med Chem
. 2006 May;
49(11):3068-76.
PMID: 16722626
Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects....
8.
Dow R, Schneider S, Paight E, Hank R, Chiang P, Cornelius P, et al.
Bioorg Med Chem Lett
. 2003 Feb;
13(3):379-82.
PMID: 12565933
In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based thyromimetics that possess up to 100-fold selectivities for binding and functional activation of the beta(1)-isoform...