Mark I Hirsh
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Explore the profile of Mark I Hirsh including associated specialties, affiliations and a list of published articles.
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10
Citations
155
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Recent Articles
1.
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W
J Leukoc Biol
. 2012 Jul;
92(4):787-94.
PMID: 22753954
Purinergic signaling plays a key role in a variety of physiological functions, including regulation of immune responses. Conventional αβ T cells release ATP upon TCR cross-linking; ATP binds to purinergic...
2.
Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh M, et al.
Shock
. 2010 Jul;
35(2):178-83.
PMID: 20661181
We reported previously that hypertonic saline (HS) treatment can prevent or upregulate the function of polymorphonuclear neutrophils (PMNs) via A2a-type adenosine receptors or A3-type adenosine receptors (A3R), respectively. A3R translocate...
3.
Hirsh M, Hashiguchi N, Junger W
Crit Care Med
. 2008 Oct;
36(12):3220-5.
PMID: 18936699
Objective: Hypertonic saline fluids used to resuscitate trauma patients can prevent neutrophil-mediated lung tissue damage, making them attractive alternatives to conventional resuscitation fluids. We have previously shown that gammadeltaT cells,...
4.
Inoue Y, Chen Y, Pauzenberger R, Hirsh M, Junger W
Crit Care Med
. 2008 Aug;
36(9):2569-75.
PMID: 18679117
Objective: Hypertonic saline resuscitation reduces tissue damage by inhibiting polymorphonuclear neutrophils. Hypertonic saline triggers polymorphonuclear neutrophils to release adenosine triphosphate that is converted to adenosine, inhibiting polymorphonuclear neutrophils through A2a...
5.
Hirsh M, Junger W
Am J Respir Cell Mol Biol
. 2008 Jun;
39(5):509-13.
PMID: 18566334
Elimination of activated inflammatory cells that infiltrate and damage host organs can reduce morbidity and mortality. A better understanding of the mechanisms by which these processes occur may lead to...
6.
A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis
Inoue Y, Chen Y, Hirsh M, Yip L, Junger W
Shock
. 2007 Dec;
30(2):173-7.
PMID: 18091570
We have recently shown that A3 adenosine receptors and P2Y2 purinergic receptors play an important role in neutrophil chemotaxis. Chemotaxis of neutrophils to sites of infections is critical for immune...
7.
Bashenko Y, Ilan N, Krausz M, Vlodavsky I, Hirsh M
Shock
. 2007 May;
28(2):207-12.
PMID: 17515848
A central event of systemic inflammation and septic organ injury is infiltration of tissues with polymorphonuclear neutrophils, likely modulated by the integrity of the extracellular matrix underlying the vascular endothelium....
8.
Hirsh M, Manov I, Cohen-Kaplan V, Iancu T
Lab Invest
. 2006 Dec;
87(2):182-8.
PMID: 17179957
Antibacterial therapy does not fully protect against anthrax because of severe systemic intoxication. Lysosomal processing of anthrax lethal toxin (LTX) is a key event in the disease pathogenesis, and agents...
9.
Hirsh M, Cohen V
J Infect Dis
. 2006 Sep;
194(7):1003-7.
PMID: 16960789
Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby...
10.
Hirsh M, Hashiguchi N, Chen Y, Yip L, Junger W
Eur J Immunol
. 2006 Feb;
36(3):712-21.
PMID: 16482515
During inflammation and sepsis, accumulation of activated neutrophils causes lung tissue damage and organ failure. Effective clearance of neutrophils reduces the risk of organ failure; however, its mechanisms are poorly...