Mark Hembree
Overview
Explore the profile of Mark Hembree including associated specialties, affiliations and a list of published articles.
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12
Citations
491
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Recent Articles
1.
Deng L, He X, Chen S, Zhang N, Deng F, Scott A, et al.
Dev Cell
. 2024 Nov;
60(3):352-363.e6.
PMID: 39579769
The homeostasis of the intestinal epithelium relies on intricate yet insufficiently understood mechanisms of intestinal epithelial plasticity. Here, we elucidate the pivotal role of Frizzled5 (Fzd5), a Wnt pathway receptor,...
2.
Dong R, Li H, He X, Wang C, Perera A, Malloy S, et al.
bioRxiv
. 2024 Jul;
PMID: 39071430
Previous studies of hematopoietic stem cells (HSCs) primarily focused on single cell-based niche models, yielding fruitful but conflicting findings . Here we report our investigation on the fetal liver (FL)...
3.
He X, Smith S, Chen S, Li H, Wu D, Meneses-Giles P, et al.
Cell Rep
. 2021 Sep;
36(10):109674.
PMID: 34496236
Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape. However, the mutual regulations between TSC and tumor microenvironment (TME) remain unclear. Using DNA-label retaining, single-cell RNA sequencing...
4.
Perry J, Tao F, Roy A, Lin T, He X, Chen S, et al.
Nat Cell Biol
. 2020 Apr;
22(6):689-700.
PMID: 32313104
Leukaemia stem cells (LSCs) underlie cancer therapy resistance but targeting these cells remains difficult. The Wnt-β-catenin and PI3K-Akt pathways cooperate to promote tumorigenesis and resistance to therapy. In a mouse...
5.
Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, et al.
Cell Stem Cell
. 2010 Mar;
6(3):194-8.
PMID: 20207221
No abstract available.
6.
Tulachan S, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, et al.
Dev Biol
. 2007 Apr;
305(2):508-21.
PMID: 17418116
Transforming growth factor-beta (TGF-beta) superfamily signaling has been implicated in many developmental processes, including pancreatic development. Previous studies are conflicting with regard to an exact role for TGF-beta signaling in...
7.
He X, Yin T, Grindley J, Tian Q, Sato T, Tao W, et al.
Nat Genet
. 2007 Jan;
39(2):189-98.
PMID: 17237784
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of the tumor suppressor...
8.
Tulachan S, Doi R, Hirai Y, Kawaguchi Y, Koizumi M, Hembree M, et al.
Dev Growth Differ
. 2006 Mar;
48(2):65-72.
PMID: 16512851
Epithelial-mesenchymal interactions are crucial for the proper development of many organs, including the pancreas. Within the pancreas, the ducts are thought to harbor stem/progenitor cells, and possibly to give rise...
9.
Tei E, Mehta S, Tulachan S, Yew H, Hembree M, Preuett B, et al.
Pancreas
. 2005 Jul;
31(2):138-41.
PMID: 16025000
Objectives: Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells....
10.
Yew K, Hembree M, Prasadan K, Preuett B, McFall C, Benjes C, et al.
J Biol Chem
. 2005 Jul;
280(37):32209-17.
PMID: 16020542
A key goal of cellular engineering is to manipulate progenitor cells to become beta-cells, allowing cell replacement therapy to cure diabetes mellitus. As a paradigm for cell engineering, we have...