George K Gittes
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Explore the profile of George K Gittes including associated specialties, affiliations and a list of published articles.
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116
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2727
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Recent Articles
1.
Svirsky S, Henchir J, Parry M, Holets E, Zhang T, Gittes G, et al.
Sci Rep
. 2024 Nov;
14(1):28998.
PMID: 39578516
Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plasticity, increases synaptogenesis and...
2.
Zhang T, Dhamotharan V, Xiao Y, Ballengee S, Pollon J, Gittes G
J Vis Exp
. 2024 May;
(207).
PMID: 38767370
Preclinical gene therapy research, particularly in rodent and large animal models, necessitates the production of AAV vectors with high yield and purity. Traditional approaches in research laboratories often involve extensive...
3.
Dahiya S, Saleh M, Rodriguez U, Rajasundaram D, R Arbujas J, Hajihassani A, et al.
Nat Commun
. 2024 May;
15(1):3740.
PMID: 38702347
Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward functional insulin-producing cells would offer an...
4.
Yoshida S, Eichelberger O, Ulis M, Kreger A, Gittes G, Church J
J Pediatr Surg
. 2024 Feb;
59(8):1515-1525.
PMID: 38350773
Background: Pulmonary hypertension remains difficult to manage in congenital diaphragmatic hernia (CDH). Prenatal therapy may ameliorate postnatal pulmonary hypertension. We hypothesized that intra-amniotic (IA) injection of either sildenafil, a phosphodiesterase...
5.
Glessner J, Ningappa M, Ngo K, Zahid M, So J, Higgs B, et al.
J Hepatol
. 2023 Aug;
79(6):1385-1395.
PMID: 37572794
Background & Aims: Biliary atresia (BA) is poorly understood and leads to liver transplantation (LT), with the requirement for and associated risks of lifelong immunosuppression, in most children. We performed...
6.
Yoshida S, Kreger A, Gittes G
Front Bioeng Biotechnol
. 2023 Aug;
11:1195623.
PMID: 37545896
Pulmonary hypertension associated with congenital diaphragmatic hernia (CDH) is a critical factor in determining prognosis. We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for CDH-induced pulmonary hypertension....
7.
Lubaczeuski C, Bozadjieva-Kramer N, Louzada R, Gittes G, Leibowitz G, Bernal-Mizrachi E
JCI Insight
. 2023 May;
8(11).
PMID: 37140984
Elevation of glucagon levels and increase in α cell proliferation is associated with states of hyperglycemia in diabetes. A better understanding of the molecular mechanisms governing glucagon secretion could have...
8.
Yoshida S, Kreger A, Shaik I, West 3rd R, Venkataramanan R, Gittes G
Toxicol Appl Pharmacol
. 2023 Apr;
469:116527.
PMID: 37080362
Background: The effectiveness of sildenafil in the management of pulmonary hypertension in congenital diaphragmatic hernia (CDH) has been reported but has not been systematically evaluated. Our studies have also demonstrated...
9.
Zou H, Poore B, Brown E, Qian J, Xie B, Asimakidou E, et al.
Nat Cell Biol
. 2023 Feb;
25(3):493-507.
PMID: 36849558
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains elusive. Here we uncover a neurodevelopmental epigenomic programme that is hijacked...
10.
Jiang Y, Wiersch J, Wu W, Qian J, Adama M, Wu N, et al.
Front Immunol
. 2023 Feb;
14:1084056.
PMID: 36733483
The contribution of bone-marrow derived cells (BMCs) to a newly formed beta-cell population in adults is controversial. Previous studies have only used models of bone marrow transplantation from sex-mismatched donors...