Mark G McLaughlin
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Explore the profile of Mark G McLaughlin including associated specialties, affiliations and a list of published articles.
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17
Citations
77
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Recent Articles
1.
Owen N, McLaughlin M
Org Biomol Chem
. 2022 Oct;
20(42):8209-8211.
PMID: 36239212
Herein, we report the development of a novel route to tricyclic lactam products a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf)/BuNPF catalyst system in...
2.
Roberts D, McLaughlin M
Chem Commun (Camb)
. 2022 Jul;
58(60):8376-8379.
PMID: 35792361
The regio and stereoselective hydrosilylation of a variety of homopropargylic alcohols and their derivatives is described. The reaction is tolerant to a variety of sterically and electronically varied substrates, affording...
3.
Basson A, Halcovitch N, McLaughlin M
Chemistry
. 2022 Jun;
28(48):e202201107.
PMID: 35642626
A range of highly functionalized polycyclic fragments have been synthesized, employing a catalytic dehydrative cyclization. A range of nucleophiles are shown to be successful, with the reaction producing numerous high...
4.
Kriek N, Nock S, Sage T, Khalifa B, Bye A, Mitchell J, et al.
Thromb Haemost
. 2022 Mar;
122(7):1115-1129.
PMID: 35253142
Cucurbitacins are dietary compounds that have been shown to elicit a range of anti-tumour, anti-inflammatory and anti-atherosclerotic activities. Originally identified as signal transducer and activator of transcription, STAT, inhibitors, a...
5.
Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds
Roberts D, McLaughlin M
Org Lett
. 2021 May;
23(11):4463-4467.
PMID: 34018758
We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic...
6.
Basson A, McLaughlin M
ChemSusChem
. 2021 Feb;
14(7):1696-1699.
PMID: 33605021
Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is...
7.
Basson A, McLaughlin M
J Org Chem
. 2020 Mar;
85(8):5615-5628.
PMID: 32208694
Herein we report our full investigation into the calcium catalyzed generation and trapping of -acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including...
8.
Britten T, McLaughlin M
J Org Chem
. 2019 Nov;
85(2):301-305.
PMID: 31775003
A mild and facile Peterson olefination has been developed employing low catalyst loading of the Brønsted acid HNTf. The reactions are typically performed at room temperature, with the reaction tolerant...
9.
Basson A, McLaughlin M
Chem Commun (Camb)
. 2019 Jul;
55(57):8317-8320.
PMID: 31257381
A rapid and functionally tolerant calcium catalysed Hosomi-Sakurai reaction has been realised. Employing 1 mol% calcium, allylated isoindolinones can be synthesised in high yields and the reaction is shown to...
10.
Le Bihan Y, Lanigan R, Atrash B, McLaughlin M, Velupillai S, Malcolm A, et al.
Eur J Med Chem
. 2019 Jun;
177:316-337.
PMID: 31158747
Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences...