Mark E OMalley
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Explore the profile of Mark E OMalley including associated specialties, affiliations and a list of published articles.
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10
Citations
402
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Recent Articles
1.
Downs-Canner S, Guo Z, Ravindranathan R, Breitbach C, OMalley M, Jones H, et al.
Mol Ther
. 2016 May;
24(8):1492-501.
PMID: 27203445
We have conducted a phase 1 study of intravenous vvDD, a Western Reserve strain oncolytic vaccinia virus, on 11 patients with standard treatment-refractory advanced colorectal or other solid cancers. The...
2.
Downs-Canner S, Magge D, Ravindranathan R, OMalley M, Francis L, Liu Z, et al.
Ann Surg Oncol
. 2015 Aug;
23(2):655-62.
PMID: 26289805
Background: Complement is a central part of both the innate and adaptive immune response and its activation has traditionally been considered part of the immunosurveillance response against cancer. Its pro-inflammatory...
3.
Zeh H, Downs-Canner S, McCart J, Guo Z, Rao U, Ramalingam L, et al.
Mol Ther
. 2014 Oct;
23(1):202-14.
PMID: 25292189
Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity. The Western Reserve strain of vaccinia virus (VV) is the most...
4.
A rationally designed A34R mutant oncolytic poxvirus: improved efficacy in peritoneal carcinomatosis
Thirunavukarasu P, Sathaiah M, Gorry M, OMalley M, Ravindranathan R, Austin F, et al.
Mol Ther
. 2013 Feb;
21(5):1024-33.
PMID: 23439499
Oncolytic poxviruses have demonstrated initial promising results in patients with cancer in clinical trials, yet further improvements are needed. It has been shown that a single point mutation in the...
5.
Choudry H, OMalley M, Guo Z, Zeh H, Bartlett D
J Surg Oncol
. 2012 May;
106(7):911-7.
PMID: 22585683
Pseudomyxoma peritonei (PMP) is characterized by intraperitoneal dissemination of mucinous ascites. This malignancy frequently recurs despite aggressive locoregional therapies, demonstrates chemo-insensitivity and lacks targeted therapies. This review addresses some intriguing...
6.
Choudry H, Mavanur A, OMalley M, Zeh H, Guo Z, Bartlett D
Ann Surg Oncol
. 2012 Feb;
19(5):1402-9.
PMID: 22302271
Background: Intraperitoneal accumulation of mucinous ascites in pseudomyxoma peritonei (PMP) promotes an inflammatory/fibrotic reaction that progresses to bowel obstruction and eventual patient demise. Cytokines and inflammation-associated transcription factor binding sites,...
7.
Li Q, OMalley M, Bartlett D, Guo Z
Mol Cancer
. 2011 May;
10:63.
PMID: 21609483
Background: Homeobox genes murine Rhox5 and human RHOXF1 are expressed in early embryonic stages and then mostly restricted to germline tissues in normal adult, yet they are aberrantly expressed in...
8.
Li Q, Bartlett D, Gorry M, OMalley M, Guo Z
Mol Pharmacol
. 2009 Aug;
76(5):1072-81.
PMID: 19679824
Epigenetic therapy of cancer using inhibitors of DNA methyltransferases (DNMT) or/and histone deacetylases (HDACs) has shown promising results in preclinical models and is being investigated in clinical trials. Homeodomain proteins...
9.
Guo Z, Naik A, OMalley M, Popovic P, DeMarco R, Hu Y, et al.
Cancer Res
. 2005 Nov;
65(21):9991-8.
PMID: 16267024
The ability of cancer cells to evade apoptosis may permit survival of a recombinant vaccinia lacking antiapoptotic genes in cancer cells compared with normal cells. We have explored the deletion...
10.
Goss J, Harley C, Mata M, OMalley M, Goins W, Hu X, et al.
Ann Neurol
. 2002 Oct;
52(5):662-5.
PMID: 12402268
We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells...