Mark C Horowitz
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Explore the profile of Mark C Horowitz including associated specialties, affiliations and a list of published articles.
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63
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2798
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Recent Articles
1.
Plummer J, Horowitz M, Johnson J
Aging Biol
. 2024 Mar;
2.
PMID: 38550776
Continuous methionine restriction (MR) is one of only a few dietary interventions known to dramatically extend mammalian healthspan. For example, continuously methionine-restricted rodents show less age-related pathology and are up...
2.
Rosen C, Horowitz M
Nat Rev Endocrinol
. 2023 Aug;
19(11):626-638.
PMID: 37587198
Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling and secreting paracrine and endocrine factors that can affect haematopoiesis, as well as potentially nourishing the bone...
3.
Jeitner T, Azcona J, Ables G, Cooke D, Horowitz M, Singh P, et al.
Geroscience
. 2023 May;
46(4):3617-3634.
PMID: 37217633
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of ...
4.
Al-Barghouthi B, Mesner L, Calabrese G, Brooks D, Tommasini S, Bouxsein M, et al.
Nat Commun
. 2021 Jun;
12(1):3408.
PMID: 34099702
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on...
5.
Fazeli P, Bredella M, Pachon-Pena G, Zhao W, Zhang X, Faje A, et al.
JCI Insight
. 2021 May;
6(12).
PMID: 33974568
BACKGROUNDAdipocytes were long considered inert components of the bone marrow niche, but mouse and human models suggest bone marrow adipose tissue (BMAT) is dynamic and responsive to hormonal and nutrient...
6.
Ferreira C, Kavanagh D, Oheim R, Zimmerman K, Sturznickel J, Li X, et al.
J Bone Miner Res
. 2021 Jan;
36(5):942-955.
PMID: 33465815
Inactivating mutations in human ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) may result in early-onset osteoporosis (EOOP) in haploinsufficiency and autosomal recessive hypophosphatemic rickets (ARHR2) in homozygous deficiency. ARHR2 patients are frequently treated with...
7.
Tratwal J, Labella R, Bravenboer N, Kerckhofs G, Douni E, Scheller E, et al.
Front Endocrinol (Lausanne)
. 2020 Mar;
11:65.
PMID: 32180758
The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer)...
8.
Oheim R, Zimmerman K, Maulding N, Sturznickel J, von Kroge S, Kavanagh D, et al.
J Bone Miner Res
. 2019 Dec;
35(3):528-539.
PMID: 31805212
Biallelic ENPP1 deficiency in humans induces generalized arterial calcification of infancy (GACI) and/or autosomal recessive hypophosphatemic rickets type 2 (ARHR2). The latter is characterized by markedly increased circulating FGF23 levels...
9.
Mensah K, Chen J, Schickel J, Isnardi I, Yamakawa N, Vega-Loza A, et al.
Sci Transl Med
. 2019 Nov;
11(519).
PMID: 31748230
Patients with rheumatoid arthritis (RA) may display atypical CD21 B cells in their blood, but the implication of this observation remains unclear. We report here that the group of patients...
10.
Sebo Z, Rendina-Ruedy E, Ables G, Lindskog D, Rodeheffer M, Fazeli P, et al.
Endocr Rev
. 2019 May;
40(5):1187-1206.
PMID: 31127816
The presence of adipocytes in mammalian bone marrow (BM) has been recognized histologically for decades, yet, until recently, these cells have received little attention from the research community. Advancements in...