Mark Badeaux
Overview
Explore the profile of Mark Badeaux including associated specialties, affiliations and a list of published articles.
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12
Citations
522
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Recent Articles
1.
Bin Sawad A, Pothukuchy A, Badeaux M, Hodson V, Bubb G, Lindsley K, et al.
JIMD Rep
. 2022 Jul;
63(4):330-340.
PMID: 35822089
Background: Arginase 1 deficiency (ARG1-D) is a rare, progressive and debilitating urea cycle disorder characterized by clinical manifestations including spasticity, seizures, developmental delay, and intellectual disability. The aim of this...
2.
Amoozgar Z, Kloepper J, Ren J, Tay R, Kazer S, Kiner E, et al.
Nat Commun
. 2021 May;
12(1):2582.
PMID: 33976133
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs...
3.
Grimes J, Khan S, Badeaux M, Rao R, Rowlinson S, Carvajal R
Int J Infect Dis
. 2020 Nov;
102:566-570.
PMID: 33160064
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a source of significant morbidity and death worldwide, and effective treatments are urgently needed. Clinical trials have...
4.
Askoxylakis V, Ferraro G, Badeaux M, Kodack D, Kirst I, Shankaraiah R, et al.
NPJ Breast Cancer
. 2019 Jan;
5:4.
PMID: 30675514
The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effects on cancer cells...
5.
Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, et al.
Nat Protoc
. 2017 Oct;
12(11):2251-2262.
PMID: 28981123
The cerebellum is a prominent part of the vertebrate hindbrain that is critically involved in the regulation of important body functions such as movement coordination, maintenance of balance and posture,...
6.
Kodack D, Askoxylakis V, Ferraro G, Sheng Q, Badeaux M, Goel S, et al.
Sci Transl Med
. 2017 May;
9(391).
PMID: 28539475
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments,...
7.
Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn L, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(5):1033-1038.
PMID: 28096337
Breast tumors contain tumorigenic cancer cells, termed "tumor-initiating cells" (TICs), which are capable of both replenishing themselves and giving rise to populations of nontumorigenic breast cancer cells (non-TICs). However, the...
8.
Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Shankaraiah R, Seano G, et al.
J Natl Cancer Inst
. 2015 Nov;
108(2).
PMID: 26547932
Background: Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer because of the disappointing efficacy of HER2-targeted...
9.
Suraneni M, Moore J, Zhang D, Badeaux M, Macaluso M, DiGiovanni J, et al.
Cell Cycle
. 2014 Apr;
13(11):1798-810.
PMID: 24732589
15-Lipoxygenase-2 (15-LOX2) is a human-specific lipid-peroxidizing enzyme most prominently expressed in epithelial cells of normal human prostate but downregulated or completely lost in>70% of prostate cancer (PCa) cases. Transgenic expression...
10.
Zhang H, Gogada R, Yadav N, Lella R, Badeaux M, Ayres M, et al.
PLoS One
. 2011 Feb;
6(1):e16379.
PMID: 21297999
In the intrinsic death pathway, cytochrome C (CC) released from mitochondria to the cytosol triggers Apaf-1 apoptosome formation and subsequent caspase activation. This process can be recapitulated using recombinant Apaf-1...