Mark A Rishavy
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Explore the profile of Mark A Rishavy including associated specialties, affiliations and a list of published articles.
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15
Citations
234
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Recent Articles
1.
Berkner K, Hallgren K, Rishavy M, Runge K
Methods Enzymol
. 2024 Nov;
708:175-205.
PMID: 39572139
The gamma-glutamyl carboxylase (GGCX) generates clusters of carboxylated glutamic acid residues in vitamin K-dependent (VKD) proteins, which is required for their diverse functions including hemostasis and regulation of calcification. The...
2.
Rishavy M, Hallgren K, Wilson L, Hiznay J, Runge K, Berkner K
Blood
. 2022 Jun;
140(15):1710-1722.
PMID: 35767717
γ-Glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout multiple Glu...
3.
Rishavy M, Hallgren K, Zhang H, Runge K, Berkner K
J Thromb Haemost
. 2019 Apr;
17(7):1053-1063.
PMID: 31009158
Background: Mutations in the γ-glutamyl carboxylase (GGCX), which is required for vitamin K-dependent (VKD) protein activation, can result in vitamin K clotting factor deficiency (VKCFD1). A recent report described a...
4.
Rishavy M, Hallgren K, Wilson L, Singh S, Runge K, Berkner K
Blood
. 2018 Mar;
131(25):2826-2835.
PMID: 29592891
The anticoagulant warfarin inhibits the vitamin K oxidoreductase (VKORC1), which generates vitamin K hydroquinone (KH) required for the carboxylation and consequent activation of vitamin K-dependent (VKD) proteins. VKORC1 produces KH...
5.
Lacombe J, Rishavy M, Berkner K, Ferron M
JCI Insight
. 2018 Jan;
3(1).
PMID: 29321368
Vertebrates possess 2 proteins with vitamin K oxidoreductase (VKOR) activity: VKORC1, whose vitamin K reduction supports vitamin K-dependent (VKD) protein carboxylation, and VKORC1-like 1 (VKORC1L1), whose function is unknown. VKD...
6.
Rishavy M, Hallgren K, Wilson L, Usubalieva A, Runge K, Berkner K
J Biol Chem
. 2013 Aug;
288(44):31556-66.
PMID: 23918929
The vitamin K oxidoreductase (VKORC1) recycles vitamin K to support the activation of vitamin K-dependent (VKD) proteins, which have diverse functions that include hemostasis and calcification. VKD proteins are activated...
7.
Rishavy M, Berkner K
Adv Nutr
. 2012 Apr;
3(2):135-48.
PMID: 22516721
The vitamin K-dependent carboxylase uses vitamin K oxygenation to drive carboxylation of multiple glutamates in vitamin K-dependent proteins, rendering them active in a variety of physiologies. Multiple carboxylations of proteins...
8.
Rishavy M, Hallgren K, Berkner K
J Biol Chem
. 2011 Sep;
286(52):44821-32.
PMID: 21896484
The γ-glutamyl carboxylase converts Glu to carboxylated Glu (Gla) to activate a large number of vitamin K-dependent proteins with diverse functions, and this broad physiological impact makes it critical to...
9.
Rishavy M, Usubalieva A, Hallgren K, Berkner K
J Biol Chem
. 2010 Oct;
286(9):7267-78.
PMID: 20978134
The vitamin K oxidoreductase (VKOR) reduces vitamin K to support the carboxylation and consequent activation of vitamin K-dependent proteins, but the mechanism of reduction is poorly understood. VKOR is an...
10.
Li Q, Grange D, Armstrong N, Whelan A, Hurley M, Rishavy M, et al.
J Invest Dermatol
. 2008 Sep;
129(3):553-63.
PMID: 18800149
A characteristic feature of classic pseudoxanthoma elasticum (PXE), an autosomal recessive disorder caused by mutations in the ABCC6 gene, is aberrant mineralization of connective tissues, particularly the elastic fibers. Here,...