Mark A McNiven
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Explore the profile of Mark A McNiven including associated specialties, affiliations and a list of published articles.
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110
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6001
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Recent Articles
1.
Schott M, Rozeveld C, Bhatt S, Crossman B, Krueger E, Weller S, et al.
Hepatol Commun
. 2024 May;
8(6).
PMID: 38780316
Background: Previous reports suggest that lipid droplets (LDs) in the hepatocyte can be catabolized by a direct engulfment from nearby endolysosomes (microlipophagy). Further, it is likely that this process is...
2.
Gutierrez-Ruiz O, Johnson K, Krueger E, Nooren R, Cruz-Reyes N, Heppelmann C, et al.
Cell Rep
. 2023 Aug;
42(9):113042.
PMID: 37651233
Amplified lysosome activity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) orchestrated by oncogenic KRAS that mediates tumor growth and metastasis, though the mechanisms underlying this phenomenon remain unclear. Using...
3.
Thomes P, Strupp M, Donohue Jr T, Kubik J, Sweeney S, Mahmud R, et al.
J Biol Chem
. 2023 Feb;
299(4):103071.
PMID: 36849008
Lipid droplets (LDs) are fat-storing organelles enclosed by a phospholipid monolayer, which harbors membrane-associated proteins that regulate distinct LD functions. LD proteins are degraded by the ubiquitin-proteasome system (UPS) and/or...
4.
Schott M, Rozeveld C, Weller S, McNiven M
J Cell Sci
. 2022 Mar;
135(5).
PMID: 35260889
Lipophagy is a central cellular process for providing the cell with a readily utilized, high energy source of neutral lipids. Since its discovery over a decade ago, we are just...
5.
Ninomiya M, Inoue J, Krueger E, Chen J, Cao H, Masamune A, et al.
Hepatol Commun
. 2021 Jul;
5(7):1238-1251.
PMID: 34278172
Currently, the hepatocellular trafficking pathways that are used by the hepatitis B virus (HBV) during viral infection and shedding are poorly defined. It is known that the HBV uses late...
6.
Wang D, Ma J, Botuyan M, Cui G, Yan Y, Ding D, et al.
Sci Adv
. 2021 Jun;
7(25).
PMID: 34144977
53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone...
7.
Drizyte-Miller K, Schott M, McNiven M
Contact (Thousand Oaks)
. 2021 Jun;
3:1-13.
PMID: 34113777
Lipid droplets (LDs) are dynamic fat-storage organelles that interact readily with numerous cellular structures and organelles. A prominent LD contact site is with degradative vesicles such as autophagosomes, lysosomes, autolysosomes,...
8.
Burton K, Johnson K, Krueger E, Razidlo G, McNiven M
Mol Biol Cell
. 2021 May;
32(15):1393-1407.
PMID: 34010028
The α-actinin family of actin cross-linking proteins have been implicated in driving tumor cell metastasis through regulation of the actin cytoskeleton; however, there has been little investigation into whether these...
9.
Rasineni K, Jordan C, Thomes P, Kubik J, Staab E, Sweeney S, et al.
Front Physiol
. 2021 Mar;
12:625352.
PMID: 33746771
Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver disease (NAFL). Though the causes of AFL and...
10.
Cao H, Qiang L, Chen J, Johnson K, McNiven M, Razidlo G
PLoS One
. 2021 Mar;
16(3):e0248111.
PMID: 33740019
The process by which tumor cells mechanically invade through the surrounding stroma into peripheral tissues is an essential component of metastatic dissemination. Matrix metalloproteinase (MMP)-mediated extracellular matrix (ECM) degradation plays...