Karuna Rasineni
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Explore the profile of Karuna Rasineni including associated specialties, affiliations and a list of published articles.
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37
Citations
479
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Recent Articles
1.
Perumal S, Day L, Arumugam M, Chava S, Kumar V, Osna N, et al.
Alcohol Clin Exp Res (Hoboken)
. 2024 Oct;
48(11):2010-2021.
PMID: 39414381
Background: The earliest manifestation of alcohol-associated liver disease (ALD) is steatosis characterized by deposition of fat in specialized organelles called lipid droplets (LDs). While alcohol administration causes a rise in...
2.
Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, et al.
Commun Biol
. 2024 May;
7(1):632.
PMID: 38796563
The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this...
3.
Schott M, Rozeveld C, Bhatt S, Crossman B, Krueger E, Weller S, et al.
Hepatol Commun
. 2024 May;
8(6).
PMID: 38780316
Background: Previous reports suggest that lipid droplets (LDs) in the hepatocyte can be catabolized by a direct engulfment from nearby endolysosomes (microlipophagy). Further, it is likely that this process is...
4.
Osna N, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, et al.
Biomolecules
. 2024 Apr;
14(4.
PMID: 38672422
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and...
5.
Mahalingam S, Bellamkonda R, Kharbanda K, Arumugam M, Kumar V, Casey C, et al.
Biomed Pharmacother
. 2024 Apr;
174():116595.
PMID: 38640709
Fatty liver is the earliest response of the liver to excessive alcohol consumption. Previously we identified that chronic alcohol administration increases levels of stomach-derived hormone, ghrelin, which by reducing circulating...
6.
Macke A, Divita T, Pachikov A, Mahalingam S, Bellamkonda R, Rasineni K, et al.
Autophagy
. 2024 Apr;
20(7):1537-1558.
PMID: 38591519
The development of alcohol-associated liver disease (ALD) is associated with disorganized Golgi apparatus and accelerated phagophore formation. While Golgi membranes may contribute to phagophores, association between Golgi alterations and macroautophagy/autophagy...
7.
Arumugam M, Gopal T, Kalari Kandy R, Boopathy L, Perumal S, Ganesan M, et al.
Biology (Basel)
. 2023 Oct;
12(10).
PMID: 37887021
The liver is a major metabolic organ that performs many essential biological functions such as detoxification and the synthesis of proteins and biochemicals necessary for digestion and growth. Any disruption...
8.
Mahalingam S, Bellamkonda R, Arumugam M, Perumal S, Yoon J, Casey C, et al.
Biochem Pharmacol
. 2023 May;
213:115613.
PMID: 37209859
Fatty liver is the earliest response to excessive ethanol consumption, which increases the susceptibility of the liver to develop advanced stage of liver disease. Our previous studies have revealed that...
9.
Arumugam M, Perumal S, Rasineni K, Donohue Jr T, Osna N, Kharbanda K
Biology (Basel)
. 2023 Mar;
12(3.
PMID: 36979154
The earliest manifestation of alcohol-associated liver disease is hepatic steatosis, which is characterized by fat accumulation in specialized organelles called lipid droplets (LDs). Our previous studies reported that alcohol consumption...
10.
Osna N, Rasineni K, Ganesan M, Donohue Jr T, Kharbanda K
J Clin Exp Hepatol
. 2022 Nov;
12(6):1492-1513.
PMID: 36340300
Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. While chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually...