Mark A McCormick
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Explore the profile of Mark A McCormick including associated specialties, affiliations and a list of published articles.
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27
Citations
712
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Recent Articles
1.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1571-1584.
PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
2.
Mariner B, Felker D, Cantergiani R, Peterson J, McCormick M
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003352
We have shown that multiple tRNA synthetase inhibitors can increase lifespan in both the nematode and the budding yeast by acting through the conserved transcription factor Gcn4 (yeast)/ATF-4 (worms). To...
3.
Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality
Scieszka D, Bolt A, McCormick M, Brigman J, Campen M
Front Toxicol
. 2023 Oct;
5:1267667.
PMID: 37900096
Aging is a complex biological process involving multiple interacting mechanisms and is being increasingly linked to environmental exposures such as wildfire smoke. In this review, we detail the hallmarks of...
4.
Mariner B, Peterson J, Taylor J, Achusim A, McCormick M
MicroPubl Biol
. 2023 Oct;
2023.
PMID: 37854099
WLSplot is an R package used to easily analyze lifespan survival data, and display results graphically as a survival curve with useful labels and statistical information auto-generated from the data...
5.
Mariner B, Rodriguez A, Heath O, McCormick M
Geroscience
. 2023 Sep;
46(2):1755-1773.
PMID: 37749371
We have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved transcription factor ATF4. Here, we show that these compounds,...
6.
Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, et al.
J Neuroinflammation
. 2023 Aug;
20(1):192.
PMID: 37608305
Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address...
7.
Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, et al.
Res Sq
. 2023 Jun;
PMID: 37333410
Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address...
8.
Robbins C, Patel B, Sawyer D, Wilkinson B, Kennedy B, McCormick M
iScience
. 2022 Nov;
25(11):105410.
PMID: 36388960
Deletion of genes encoding ribosomal proteins extends lifespan in yeast. This increases translation of the functionally conserved transcription factor Gcn4, and lifespan extension in these mutants is dependent. Gcn4 is...
9.
Wang J, Sang Y, Jin S, Wang X, Azad G, McCormick M, et al.
Aging Cell
. 2022 Oct;
21(11):e13712.
PMID: 36181361
The budding yeast Saccharomyces cerevisiae (S. cerevisiae) has relatively short lifespan and is genetically tractable, making it a widely used model organism in aging research. Here, we carried out a...
10.
Small E, Felker D, Heath O, Cantergiani R, Osley M, McCormick M
Transl Med Aging
. 2021 Feb;
4:141-148.
PMID: 33542965
Plate reader-based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast genetics. These methods have...