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Marjan Slak Rupnik

Explore the profile of Marjan Slak Rupnik including associated specialties, affiliations and a list of published articles. Areas
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Articles 51
Citations 1009
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Recent Articles
1.
Rupnik M
Elife . 2025 Feb; 14. PMID: 39936640
Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
2.
Huber M, Widener A, Cuaycal A, Smurlick D, Butterworth E, Lenchik N, et al.
bioRxiv . 2025 Jan; PMID: 39763971
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often have a...
3.
Napoli M, Immler R, Rohwedder I, Lupperger V, Pfabe J, Gonzalez Pisfil M, et al.
Elife . 2024 Dec; 13. PMID: 39699020
S100A8/A9 is an endogenous alarmin secreted by myeloid cells during many acute and chronic inflammatory disorders. Despite increasing evidence of the proinflammatory effects of extracellular S100A8/A9, little is known about...
4.
Heber S, Wagner-Menghin M, Volf I, Rupnik M, Schmid D, Marz R, et al.
Med Educ Online . 2024 Sep; 29(1):2397864. PMID: 39238153
Assigning students to work in permanent teams is a design principle in Team-based learning (TBL). It has been assumed that a stable team composition supports the emergence of collaborative problem-solving...
5.
Lee C, Kono T, Syed F, Weaver S, Sohn P, Wu W, et al.
FASEB J . 2024 Aug; 38(15):e23853. PMID: 39120544
Sodium butyrate (NaB) improves β-cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been fully elucidated. In this study, we investigated the impact...
6.
Leitgeb E, Kercmar J, Krizancic Bombek L, Pohorec V, Klemen M, Rupnik M, et al.
Front Endocrinol (Lausanne) . 2024 Jan; 14:1315520. PMID: 38292770
Tight control of beta cell stimulus-secretion coupling is crucial for maintaining homeostasis of energy-rich nutrients. While glucose serves as a primary regulator of this process, incretins augment beta cell function,...
7.
Rupnik M, Hara M
Diabetes . 2024 Jan; 73(4):533-541. PMID: 38215069
Article Highlights:
8.
Lee C, Kono T, Syed F, Weaver S, Sohn P, Wu W, et al.
bioRxiv . 2023 Dec; PMID: 38106138
Histone deacetylase inhibitors (HDIs) modulate β cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been determined. In this study, we investigated the...
9.
Klemen M, Dolensek J, Krizancic Bombek L, Pohorec V, Gosak M, Rupnik M, et al.
Front Endocrinol (Lausanne) . 2023 Sep; 14:1225486. PMID: 37701894
Beta cells couple stimulation by glucose with insulin secretion and impairments in this coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) amplifies stimulus-secretion coupling via protein...
10.
Sohn P, McLaughlin M, Krishnan P, Wu W, Rupnik M, Takasu A, et al.
Diabetes . 2023 Jul; 72(10):1433-1445. PMID: 37478155
Article Highlights: Store-operated Ca2+ entry replenishes endoplasmic reticulum (ER) Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). β-Cell-specific deletion...