Mariyan J Jeyarajah
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Explore the profile of Mariyan J Jeyarajah including associated specialties, affiliations and a list of published articles.
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11
Citations
148
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Recent Articles
1.
Jeyarajah M, Patterson V, Jaju Bhattad G, Zhao L, Whitehead S, Renaud S
Commun Biol
. 2024 Oct;
7(1):1254.
PMID: 39363116
Congenital heart defects are leading causes of neonatal mortality and are often associated with placental abnormalities, but mechanisms linking placenta and heart development are poorly understood. Herein, we investigated a...
2.
Cinkornpumin J, Kwon S, Prandstetter A, Maxian T, Sirois J, Goldberg J, et al.
bioRxiv
. 2024 Sep;
PMID: 39314437
The placenta develops alongside the embryo and nurtures fetal development to term. During the first stages of embryonic development, due to low blood circulation, the blood and ambient oxygen supply...
3.
Jaremek A, Shaha S, Jeyarajah M, Jaju Bhattad G, Chowdhury D, Riddell M, et al.
Am J Pathol
. 2023 Apr;
193(7):846-865.
PMID: 37028593
Preeclampsia (PE) is a common and serious complication of pregnancy with no cure except premature delivery. The root cause of PE is improper development of the placenta-the temporary organ supporting...
4.
Jeyarajah M, Jaju Bhattad G, Kelly R, Baines K, Jaremek A, Yang F, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(49):e2203071119.
PMID: 36442132
Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical complications like preeclampsia, intrauterine growth...
5.
Renaud S, Jeyarajah M
Cell Mol Life Sci
. 2022 Jul;
79(8):433.
PMID: 35859055
In humans, cell fusion is restricted to only a few cell types under normal conditions. In the placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant multinucleated...
6.
Roberts H, Woodman A, Baines K, Jeyarajah M, Bourque S, Renaud S
Endocrinology
. 2021 Oct;
162(12).
PMID: 34647996
Iron deficiency, which occurs when iron demands chronically exceed intake, is prevalent in pregnant women. Iron deficiency during pregnancy poses major risks for the baby, including fetal growth restriction and...
7.
Jaremek A, Jeyarajah M, Jaju Bhattad G, Renaud S
Front Cell Dev Biol
. 2021 Jul;
9:674162.
PMID: 34211975
Proper development of the placenta is vital for pregnancy success. The placenta regulates exchange of nutrients and gases between maternal and fetal blood and produces hormones essential to maintain pregnancy....
8.
Jaju Bhattad G, Jeyarajah M, McGill M, Dumeaux V, Okae H, Arima T, et al.
Cell Death Dis
. 2020 May;
11(5):311.
PMID: 32366868
Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue,...
9.
Jeyarajah M, Jaju Bhattad G, Hillier D, Renaud S
Cells
. 2020 Apr;
9(4).
PMID: 32244352
Trophoblasts are the first cell type to be specified during embryogenesis, and they are essential for placental morphogenesis and function. Trophoblast stem (TS) cells are the progenitor cells for all...
10.
Baines K, Rampersaud A, Hillier D, Jeyarajah M, Grafham G, Eastabrook G, et al.
J Immunol
. 2019 Dec;
204(3):694-706.
PMID: 31882516
Many viruses are detrimental to pregnancy and negatively affect fetal growth and development. What is not well understood is how virus-induced inflammation impacts fetal-placental growth and developmental trajectories, particularly when...