Marissa A Scavuzzo
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Explore the profile of Marissa A Scavuzzo including associated specialties, affiliations and a list of published articles.
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19
Citations
439
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Recent Articles
11.
Scavuzzo M, Chmielowiec J, Yang D, Wamble K, Chaboub L, Duraine L, et al.
Cell Rep
. 2018 Dec;
25(13):3811-3827.e7.
PMID: 30590051
Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate into endocrine cells, they must escape Notch activation to express Neurogenin-3. Here, we find that the transcription factor...
12.
Scavuzzo M, Hill M, Chmielowiec J, Yang D, Teaw J, Sheng K, et al.
Nat Commun
. 2018 Aug;
9(1):3356.
PMID: 30135482
Decoding the molecular composition of individual Ngn3 + endocrine progenitors (EPs) during pancreatic morphogenesis could provide insight into the mechanisms regulating hormonal cell fate. Here, we identify population markers and...
13.
Scavuzzo M, Teaw J, Yang D, Borowiak M
J Vis Exp
. 2018 Jun;
(136).
PMID: 29912186
The pancreas is a complex organ composed of many different cell types that work together to regulate blood glucose homeostasis and digestion. These cell types include enzyme-secreting acinar cells, an...
14.
Sprouse M, Scavuzzo M, Blum S, Shevchenko I, Lee T, Makedonas G, et al.
JCI Insight
. 2018 Jan;
3(2).
PMID: 29367462
T cell receptor (TCR) affinity is a critical factor of Treg lineage commitment, but whether self-reactivity is a determining factor in peripheral Treg function remains unknown. Here, we report that...
15.
Sprouse M, Shevchenko I, Scavuzzo M, Joseph F, Lee T, Blum S, et al.
J Immunol
. 2017 Dec;
200(3):909-914.
PMID: 29282307
Regulatory T cells (Tregs) use a distinct TCR repertoire and are more self-reactive compared with conventional T cells. However, the extent to which TCR affinity regulates the function of self-reactive...
16.
Scavuzzo M, Yang D, Borowiak M
Sci Rep
. 2017 Sep;
7(1):10810.
PMID: 28883507
Replacement of lost beta cells in patients with diabetes has the potential to alleviate them of their disease, yet current protocols to make beta cells are inadequate for therapy. In...
17.
18.
Yang D, Scavuzzo M, Chmielowiec J, Sharp R, Bajic A, Borowiak M
Sci Rep
. 2016 Feb;
6:21264.
PMID: 26887909
Efficient gene editing is essential to fully utilize human pluripotent stem cells (hPSCs) in regenerative medicine. Custom endonuclease-based gene targeting involves two mechanisms of DNA repair: homology directed repair (HDR)...
19.
Singh R, Xia Z, Bland C, Kalsotra A, Scavuzzo M, Curk T, et al.
Mol Cell
. 2014 Aug;
55(4):592-603.
PMID: 25087874
Alternative splicing plays important regulatory roles during periods of physiological change. During development, a large number of genes coordinately express protein isoform transitions regulated by alternative splicing; however, the mechanisms...
20.
Giudice J, Xia Z, Wang E, Scavuzzo M, Ward A, Kalsotra A, et al.
Nat Commun
. 2014 Apr;
5:3603.
PMID: 24752171
During postnatal development the heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). Here we perform deep RNA-sequencing on RNA...