Mario Zierden
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Explore the profile of Mario Zierden including associated specialties, affiliations and a list of published articles.
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8
Citations
75
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Recent Articles
1.
Zierden M, Berghausen E, Gnatzy-Feik L, Millarg C, Picard F, Kiljan M, et al.
JCI Insight
. 2024 Oct;
9(22).
PMID: 39378110
Chronic activation of the adaptive immune system is a hallmark of atherosclerosis. As PI3Kδ is a key regulator of T and B cell differentiation and function, we hypothesized that alleviation...
2.
Paunel-Gorgulu A, Conforti A, Mierau N, Zierden M, Xiong X, Wahlers T
Front Cardiovasc Med
. 2022 Dec;
9:1046273.
PMID: 36465436
Introduction: Despite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood. In this regard, PAD4 deletion or inhibition of enzymatic activity...
3.
Berghausen E, Janssen W, Vantler M, Gnatzy-Feik L, Krause M, Behringer A, et al.
J Clin Invest
. 2021 Oct;
131(19).
PMID: 34596056
Enhanced signaling via RTKs in pulmonary hypertension (PH) impedes current treatment options because it perpetuates proliferation and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs). Here, we demonstrated hyperphosphorylation...
4.
Batool M, Berghausen E, Zierden M, Vantler M, Schermuly R, Baldus S, et al.
Basic Res Cardiol
. 2020 Nov;
115(6):68.
PMID: 33188479
Six-transmembrane protein of prostate (Stamp2) protects from diabetes and atherosclerosis in mice via anti-inflammatory mechanisms. As chronic inflammation is a hallmark of pulmonary arterial hypertension (PAH), we investigated the role...
5.
Vantler M, Jesus J, Leppanen O, Scherner M, Berghausen E, Mustafov L, et al.
Arterioscler Thromb Vasc Biol
. 2015 Apr;
35(6):1434-44.
PMID: 25908763
Objective: Neointima formation after vascular injury remains a significant problem in clinical cardiology, and current preventive strategies are suboptimal. Phosphatidylinositol 3'-kinase is a central downstream mediator of growth factor signaling,...
6.
Freyhaus H, Berghausen E, Janssen W, Leuchs M, Zierden M, Murmann K, et al.
Arterioscler Thromb Vasc Biol
. 2015 Mar;
35(5):1236-45.
PMID: 25745058
Objective: Despite modern therapies, pulmonary arterial hypertension (PAH) harbors a high mortality. Vascular remodeling is a hallmark of the disease. Recent clinical studies revealed that antiremodeling approaches with tyrosine-kinase inhibitors...
7.
Zierden M, Penner A, Montesinos-Rongen M, Weferling M, Drebber U, Stift J, et al.
Virchows Arch
. 2012 Mar;
460(4):389-97.
PMID: 22419260
Keratins 8 and 18 (K8 and K18) are the cytoskeletal intermediate filament proteins of adult hepatocytes. Murine models indicate that mutations in the K8- and K18-encoding genes predispose to liver...
8.
Zierden M, Kuhnen E, Odenthal M, Dienes H
Gastroenterology
. 2010 Jul;
139(3):975-86, 986.e1-3.
PMID: 20639127
Background & Aims: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown etiology. Autoreactive T cells are thought to mediate liver injury, but the pathogenesis of AIH is...