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Mario Picciani

Explore the profile of Mario Picciani including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 19
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Recent Articles
1.
Hoffmann M, Poschenrieder J, Incudini M, Baier S, Fritz A, Maier A, et al.
Nucleic Acids Res . 2024 Aug; 52(17):10144-10160. PMID: 39175109
Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) (1-3). Existing...
2.
The M, Picciani M, Jensen C, Gabriel W, Kuster B, Wilhelm M
Methods Mol Biol . 2024 Jul; 2836:157-181. PMID: 38995541
Proteomics, the study of proteins within biological systems, has seen remarkable advancements in recent years, with protein isoform detection emerging as one of the next major frontiers. One of the...
3.
Kalhor M, Lapin J, Picciani M, Wilhelm M
Mol Cell Proteomics . 2024 Jun; 23(7):100798. PMID: 38871251
Rescoring of peptide spectrum matches originating from database search engines enabled by peptide property predictors is exceeding the performance of peptide identification from traditional database search engines. In contrast to...
4.
Adams C, Gabriel W, Laukens K, Picciani M, Wilhelm M, Bittremieux W, et al.
Nat Commun . 2024 May; 15(1):3956. PMID: 38730277
Immunopeptidomics is crucial for immunotherapy and vaccine development. Because the generation of immunopeptides from their parent proteins does not adhere to clear-cut rules, rather than being able to use known...
5.
Gabriel W, Picciani M, The M, Wilhelm M
Methods Mol Biol . 2024 Mar; 2758:457-483. PMID: 38549030
Liquid chromatography-coupled mass spectrometry (LC-MS/MS) is the primary method to obtain direct evidence for the presentation of disease- or patient-specific human leukocyte antigen (HLA). However, compared to the analysis of...
6.
Hoffmann M, Poschenrieder J, Incudini M, Baier S, Fitz A, Maier A, et al.
medRxiv . 2023 Dec; PMID: 38076997
Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs). Existing statistical...
7.
Picciani M, Gabriel W, Giurcoiu V, Shouman O, Hamood F, Lautenbacher L, et al.
Proteomics . 2023 Sep; 24(8):e2300112. PMID: 37672792
Machine learning (ML) and deep learning (DL) models for peptide property prediction such as Prosit have enabled the creation of high quality in silico reference libraries. These libraries are used...