Marika Kaakinen
Overview
Explore the profile of Marika Kaakinen including associated specialties, affiliations and a list of published articles.
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85
Citations
11540
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Recent Articles
1.
Burrows K, Heiskala A, Bradfield J, Balkhiyarova Z, Ning L, Boissel M, et al.
Nat Commun
. 2024 Nov;
15(1):10067.
PMID: 39567492
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to...
2.
Bradfeld J, Kember R, Ulrich A, Balkhiyarova Z, Alyass A, Aris I, et al.
Genome Biol
. 2024 May;
25(1):129.
PMID: 38773652
No abstract available.
3.
Pascat V, Zudina L, Ulrich A, Maina J, Kaakinen M, Pupko I, et al.
Hum Hered
. 2024 May;
89(1):60-70.
PMID: 38740014
Introduction: Polygenic score (PGS) is a valuable method for assessing the estimated genetic liability to a given outcome or genetic variability contributing to a quantitative trait. While polygenic risk scores...
4.
Burrows K, Heiskala A, Bradfield J, Balkhiyarova Z, Ning L, Boissel M, et al.
medRxiv
. 2024 Apr;
PMID: 38559031
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to...
5.
Bradfield J, Kember R, Ulrich A, Balkhiyarova Z, Alyass A, Aris I, et al.
Genome Biol
. 2024 Jan;
25(1):22.
PMID: 38229171
Background: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And...
6.
7.
Maina J, Balkhiyarova Z, Nouwen A, Pupko I, Ulrich A, Boissel M, et al.
Diabetes Care
. 2023 Jul;
46(9):1707-1714.
PMID: 37494602
Objective: Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them. Research Design And Methods: We applied two-sample, bidirectional Mendelian randomization...
8.
Maina J, Pascat V, Zudina L, Ulrich A, Pupko I, Bonnefond A, et al.
Eur J Hum Genet
. 2023 May;
31(8):962-966.
PMID: 37161092
Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between pancreatic cancer and two distinct measures of obesity, namely total...
9.
Balkhiyarova Z, Luciano R, Kaakinen M, Ulrich A, Shmeliov A, Bianchi M, et al.
Hum Mol Genet
. 2021 Sep;
31(5):816-826.
PMID: 34590674
Epidemic obesity is the most important risk factor for prediabetes and type 2 diabetes (T2D) in youth as it is in adults. Obesity shares pathophysiological mechanisms with T2D and is...
10.
Alves A, De Silva N, Karhunen V, Sovio U, Das S, Taal H, et al.
Sci Adv
. 2019 Dec;
5(9):eaaw3095.
PMID: 31840077
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling...