Mariela Castelblanco
Overview
Explore the profile of Mariela Castelblanco including associated specialties, affiliations and a list of published articles.
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7
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101
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Recent Articles
1.
Ehirchiou D, Bernabei I, Durairaj Pandian V, Nasi S, Chobaz V, Castelblanco M, et al.
Arthritis Res Ther
. 2024 Jun;
26(1):119.
PMID: 38863059
Objective: In gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and the maturation of IL-1β. This study aimed to investigate the role...
2.
Nasi S, Ehirchiou D, Bertrand J, Castelblanco M, Mitchell J, Ishii I, et al.
Antioxidants (Basel)
. 2021 Sep;
10(9).
PMID: 34573065
Pathologic calcification (PC) is a painful and disabling condition whereby calcium-containing crystals deposit in tissues that do not physiologically calcify: cartilage, tendons, muscle, vessels and skin. In cartilage, compression and...
3.
Nasi S, Castelblanco M, Chobaz V, Ehirchiou D, So A, Bernabei I, et al.
Front Cell Dev Biol
. 2021 Feb;
9:612440.
PMID: 33634117
Pathologic calcification of cartilage consists of the formation of basic calcium phosphate (BCP) and/or calcium pyrophosphate dihydrate (CPPD) containing calcium crystals in mature hyaline or articular cartilage and is associated...
4.
Ehirchiou D, Bernabei I, Chobaz V, Castelblanco M, Hugle T, So A, et al.
Front Cell Dev Biol
. 2021 Jan;
8:611757.
PMID: 33392201
Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification. However, this calcification process is poorly understood...
5.
Kusano T, Ehirchiou D, Matsumura T, Chobaz V, Nasi S, Castelblanco M, et al.
Nat Commun
. 2019 Oct;
10(1):4904.
PMID: 31659168
Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce...
6.
Castelblanco M, Nasi S, Pasch A, So A, Busso N
Br J Pharmacol
. 2019 Jun;
177(4):778-792.
PMID: 31231793
Calcification is the deposition of minerals, mainly hydroxyapatite, inside the cell or in the extracellular matrix. Physiological calcification is central for many aspects of development including skeletal and tooth growth;...
7.
Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, et al.
J Biol Chem
. 2017 Dec;
293(7):2546-2557.
PMID: 29279328
A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Upon oligomerization...