Marianna Yakubovskaya
Overview
Explore the profile of Marianna Yakubovskaya including associated specialties, affiliations and a list of published articles.
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15
Citations
192
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Recent Articles
1.
Vlasova O, Antonova I, Magomedova K, Osipova A, Shtompel P, Borunova A, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796235
Previously we discovered that among 15 DNA-binding plant secondary metabolites (PSMs) possessing anticancer activity, 11 compounds cause depletion of the chromatin-bound linker histones H1.2 and/or H1.4. Chromatin remodeling or multiH1...
2.
Vlasova O, Antonova I, Zenkov R, Naberezhnov D, Belitsky G, Borunova A, et al.
Front Biosci (Landmark Ed)
. 2024 Aug;
29(8):275.
PMID: 39206902
Background: Many plant secondary metabolites (PSMs) were shown to intercalate into DNA helix or interact with DNA grooves. This may influence histone-DNA interactions changeing chromatin structure and genome functioning. Methods:...
3.
Avagimyan A, Pogosova N, Kakturskiy L, Sheibani M, Challa A, Kogan E, et al.
Cardiovasc Pathol
. 2024 Aug;
73:107683.
PMID: 39111556
Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged...
4.
Kalinina A, Tilova L, Kirsanov K, Lesovaya E, Zhidkova E, Fetisov T, et al.
Toxicology
. 2023 Nov;
500:153675.
PMID: 37993081
Chronic inflammation is associated with malignant transformation and creates the microenvironment for tumor progression. Cyclophilin A (CypA) is one of the major pro-inflammatory mediators that accumulates and persists in the...
5.
Maksimova V, Makus J, Popova V, Prus A, Usalka O, Trapeznikova E, et al.
Biochemistry (Mosc)
. 2023 Sep;
88(7):968-978.
PMID: 37751867
Epigenetic genome regulation during malignant cell transformation is characterized by the aberrant methylation and acetylation of histones. Vorinostat (SAHA) is an epigenetic modulator actively used in clinical oncology. The antitumor...
6.
Maksimova V, Popova V, Prus A, Lylova E, Usalka O, Sagitova G, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37629054
The development of malignant tumors is caused by a complex combination of genetic mutations and epigenetic alterations, the latter of which are induced by either external environmental factors or signaling...
7.
Nichugovskiy A, Maksimova V, Trapeznikova E, Eshtukova-Shcheglova E, Ivanov I, Yakubovskaya M, et al.
Molecules
. 2022 Oct;
27(19).
PMID: 36234753
Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the cell death of various cancer cell lines. In the...
8.
Kirsanov K, Fetisov T, Antoshina E, Trukhanova L, Gorkova T, Vlasova O, et al.
Front Pharmacol
. 2022 Jul;
13:842316.
PMID: 35873588
7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it...
9.
Maksimova V, Shalginskikh N, Vlasova O, Usalka O, Beizer A, Bugaeva P, et al.
PLoS One
. 2021 Jun;
16(6):e0252504.
PMID: 34115770
Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can strongly influence the expression of genes and endogenous retroviral...
10.
Belitsky G, Fetisov T, Kirsanov K, Lesovaya E, Vlasova O, Yakubovskaya M
Am J Blood Res
. 2021 Jan;
10(6):416-433.
PMID: 33489451
Background: Secondary tumors, including therapy-related acute myeloid leukemia (t-AML), represent one of the most undesirable side effects of chemotherapy, which arise several years after primary cancer treatment. This review aims...