Maria Salmela
Overview
Explore the profile of Maria Salmela including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
92
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0
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Recent Articles
1.
Munne P, Martikainen L, Raty I, Bertula K, Nonappa , Ruuska J, et al.
Nat Commun
. 2021 Nov;
12(1):6967.
PMID: 34845227
Breast cancer is now globally the most frequent cancer and leading cause of women's death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that...
2.
Salmela M, Jokinen J, Tiitta S, Rappu P, Cheng R, Heino J
Sci Rep
. 2017 Jun;
7(1):3414.
PMID: 28611383
Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large...
3.
Salmela M, Rappu P, Lilja J, Niskanen H, Taipalus E, Jokinen J, et al.
Int J Biochem Cell Biol
. 2016 Jul;
78:22-30.
PMID: 27373681
Phorbol diester PMA (phorbol 12-myristate 13-acetate) is a well-known promoter of tumor progression. PMA also regulates cell adhesion by several mechanisms including conformational activation of integrins and integrin clustering. Here,...
4.
Santio N, Salmela M, Arola H, Eerola S, Heino J, Rainio E, et al.
Exp Cell Res
. 2016 Mar;
342(2):113-24.
PMID: 26934497
The ability of cells to migrate and form metastases is one of the fatal hallmarks of cancer that can be conquered only with better understanding of the molecules and regulatory...
5.
Nissinen L, Koivunen J, Kapyla J, Salmela M, Nieminen J, Jokinen J, et al.
J Biol Chem
. 2012 Nov;
287(53):44694-702.
PMID: 23132859
The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formation. Here, we describe two structurally similar sulfonamide derivatives, BTT-3033 and BTT-3034,...
6.
Jokinen J, White D, Salmela M, Huhtala M, Kapyla J, Sipila K, et al.
EMBO J
. 2009 Nov;
29(1):196-208.
PMID: 19927126
Conformational activation increases the affinity of integrins to their ligands. On ligand binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the natural ligands of alpha2beta1 integrin,...