Maria J Matos
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Explore the profile of Maria J Matos including associated specialties, affiliations and a list of published articles.
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42
Citations
516
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Recent Articles
1.
Cabezas D, Mellado G, Espinoza N, Garate J, Morales C, Castro-Alvarez A, et al.
J Biomol Struct Dyn
. 2023 Jan;
41(22):13250-13259.
PMID: 36718094
Glycogen synthase kinase 3 (GSK-3) is involved in different diseases, such as manic-depressive illness, Alzheimer's disease and cancer. Studies have shown that insulin inhibits GSK-3 to keep glycogen synthase active....
2.
Matos M, Novo P, Mayan L, Torres I, Uriarte E, Yanez M, et al.
Eur J Med Chem
. 2023 Jan;
248:115091.
PMID: 36638711
Psychiatric and neurological disorders affect millions of people worldwide. Currently available treatments may help to improve symptoms, but they cannot cure the diseases. Therefore, there is an urgent need for...
3.
Matos M, Santana L, Uriarte E, Borges F
Molecules
. 2022 Aug;
27(15).
PMID: 35956851
Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins...
4.
Delogu G, Fais A, Pintus F, Goyal C, Matos M, Era B, et al.
Pharmaceuticals (Basel)
. 2022 Mar;
15(3).
PMID: 35337102
In the present work, we use a merger of computational and biochemical techniques as a rational guideline for structural modification of benzofuran derivatives to find pertinent structural features for the...
5.
Ferhati X, Jimenez-Moreno E, Hoyt E, Salluce G, Cabeza-Cabrerizo M, Navo C, et al.
J Am Chem Soc
. 2022 Mar;
144(12):5284-5294.
PMID: 35293206
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics used to selectively kill cancer cells. It is important that they remain intact in the bloodstream and release their payload in...
6.
Mellado M, Gonzalez C, Mella J, Aguilar L, Celik I, Borges F, et al.
Molecules
. 2022 Feb;
27(3).
PMID: 35164192
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the...
7.
Matos M, Uriarte E, Santana L
Molecules
. 2021 Nov;
26(21).
PMID: 34771164
3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed,...
8.
Guardado Yordi E, Santana L, Uriarte E, Borges F, Matos M
Curr Top Med Chem
. 2021 Oct;
21(25):2245-2257.
PMID: 34635041
Computer-aided design of new drugs is an exponentially growing field, especially in the last decade. The support of theoretical tools may accelerate the drug discovery process, which is a long...
9.
Mellado M, Gonzalez C, Mella J, Aguilar L, Vina D, Uriarte E, et al.
Bioorg Chem
. 2021 Feb;
108:104689.
PMID: 33571810
Monoamine oxidases (MAOs) are important targets in medicinal chemistry, as their inhibition may change the levels of different neurotransmitters in the brain, and also the production of oxidative stress species....
10.
Matos M, Brown L, Bernardim B, Guerreiro A, Jimenez-Oses G, Bernardes G
Bioorg Med Chem
. 2020 Oct;
28(22):115783.
PMID: 33007561
Methods that allow for chemical site-selective dual protein modification are scarce. Here, we provide proof-of-concept for the orthogonality and compatibility of a method for regioselective lysine modification with strategies for...