Maria I Zavodszky
Overview
Explore the profile of Maria I Zavodszky including associated specialties, affiliations and a list of published articles.
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24
Citations
378
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Recent Articles
1.
Hawley Z, Pardo I, Cao S, Zavodszky M, Casey F, Ferber K, et al.
Mol Ther
. 2024 Nov;
33(1):215-234.
PMID: 39563026
Dorsal root ganglion (DRG) toxicity has been consistently reported as a potential safety concern after delivery of adeno-associated viruses (AAVs) containing gene-replacement vectors but has yet to be reported for...
2.
Chen S, Hawley Z, Zavodszky M, Hana S, Ferretti D, Grubor B, et al.
Mol Ther Nucleic Acids
. 2023 Nov;
34:102057.
PMID: 37928442
Toxic gain-of-function mutations in superoxide dismutase 1 (SOD1) contribute to approximately 2%-3% of all amyotrophic lateral sclerosis (ALS) cases. Artificial microRNAs (amiRs) delivered by adeno-associated virus (AAV) have been proposed...
3.
Li K, Sun Y, Ouyang Z, Negi S, Gao Z, Zhu J, et al.
BMC Genomics
. 2023 May;
24(1):228.
PMID: 37131143
Background: Single-cell RNA sequencing is a state-of-the-art technology to understand gene expression in complex tissues. With the growing amount of data being generated, the standardization and automation of data analysis...
4.
de Klein N, Tsai E, Vochteloo M, Baird D, Huang Y, Chen C, et al.
Nat Genet
. 2023 Feb;
55(3):377-388.
PMID: 36823318
Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and...
5.
Zhu J, Sun Y, Ouyang Z, Li K, Negi S, Piya S, et al.
J Mol Biol
. 2023 Feb;
435(14):168017.
PMID: 36806691
We present RNASequest, a customizable RNA sequencing (RNAseq) analysis, app management, and result publishing framework. Its three-in-one RNAseq data analysis ecosystem consists of (1) a reproducible, configurable expression analysis (EA)...
6.
Chen Y, Kankel M, Hana S, Lau S, Zavodszky M, McKissick O, et al.
Gene Ther
. 2022 Nov;
30(5):443-454.
PMID: 36450833
CRISPR-based gene editing technology represents a promising approach to deliver therapies for inherited disorders, including amyotrophic lateral sclerosis (ALS). Toxic gain-of-function superoxide dismutase 1 (SOD1) mutations are responsible for ~20%...
7.
Ouyang Z, Bourgeois-Tchir N, Lyashenko E, Cundiff P, Cullen P, Challa R, et al.
Sci Rep
. 2022 Oct;
12(1):17394.
PMID: 36253414
Induced pluripotent stem cell (iPSC) derived cell types are increasingly employed as in vitro model systems for drug discovery. For these studies to be meaningful, it is important to understand...
8.
Berens M, Sood A, Barnholtz-Sloan J, Graf J, Cho S, Kim S, et al.
PLoS One
. 2019 Dec;
14(12):e0219724.
PMID: 31881020
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the...
9.
Newberg L, Chen X, Kodira C, Zavodszky M
PLoS One
. 2018 Mar;
13(3):e0193067.
PMID: 29494600
Bulk tissue samples examined by gene expression studies are usually heterogeneous. The data gained from these samples display the confounding patterns of mixtures consisting of multiple cell types or similar...
10.
Graf J, Zavodszky M
PLoS One
. 2017 Dec;
12(11):e0188878.
PMID: 29190747
Background: Tumor heterogeneity can manifest itself by sub-populations of cells having distinct phenotypic profiles expressed as diverse molecular, morphological and spatial distributions. This inherent heterogeneity poses challenges in terms of...