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Maria Hukkinen

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Articles 49
Citations 267
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Recent Articles
1.
Anderson L, Hukkinen M, Nyholm I, Niemi M, Pakarinen M
J Pediatr Gastroenterol Nutr . 2025 Mar; 80(3):462-470. PMID: 40028801
Objectives: To compare the predictive value of serum bile acids on native liver survival (NLS) and portal hypertension (PH) at various time points early after portoenterostomy (PE) in biliary atresia...
2.
Hulscher J, Irvine W, Conforti A, Di Cesare A, Ichino M, Sfeir R, et al.
Neonatology . 2025 Feb; :1-9. PMID: 39925108
Necrotizing enterocolitis (NEC) is a severe intestinal condition primarily affecting preterm neonates. It has a high mortality rate, particularly in infants with a birthweight of below 1,500 g or for...
3.
Nyholm I, Hukkinen M, Lohi J, Sjoblom N, Mutka A, Mutanen A, et al.
J Hepatol . 2025 Jan; PMID: 39889904
Background & Aims: Little is known on the mechanism of liver injury mediated by bile acids following Kasai portoenterostomy (KPE) in biliary atresia (BA). We sought to quantify individual serum...
4.
Nyholm I, Hukkinen M, Pakarinen M
Semin Pediatr Surg . 2025 Jan; 33(6):151473. PMID: 39884181
Regardless of the underlying etiology and success of PE, progressive liver fibrosis and eventually cirrhosis represent the dominant pathology and the end-stage of BA. Ascending bile duct injury-induced cholestasis, inflammation...
5.
Tam P, Wells R, Tang C, Lui V, Hukkinen M, Luque C, et al.
Nat Rev Dis Primers . 2024 Jul; 10(1):47. PMID: 38992031
Biliary atresia (BA) is a progressive inflammatory fibrosclerosing disease of the biliary system and a major cause of neonatal cholestasis. It affects 1:5,000-20,000 live births, with the highest incidence in...
6.
Jahnukainen T, Sareneva I, Lauronen J, Ylinen E, Tainio J, Nordin A, et al.
Ann Transplant . 2024 Feb; 29:e941929. PMID: 38347714
BACKGROUND The use of ABO-incompatible liver transplants (ABO-ILTs) from deceased donors has become more common due to the shortage of available donor livers and increased transplant waiting times. This retrospective...
7.
Nyholm I, Sjoblom N, Pihlajoki M, Hukkinen M, Lohi J, Heikkila P, et al.
Hepatol Commun . 2023 Dec; 7(12). PMID: 38051554
Background: We aimed to quantify ductular reaction (DR) in biliary atresia using a neural network in relation to underlying pathophysiology and prognosis. Methods: Image-processing neural network model was applied to...
8.
Nieminen O, Hukkinen M, Kivisaari R, Mutanen A, Merras-Salmio L, Pakarinen M
J Pediatr Gastroenterol Nutr . 2023 Sep; 77(6):720-725. PMID: 37679875
Objectives: Although excessive intestinal dilatation associates with worsened outcomes in pediatric short bowel syndrome (SBS), little is known about the natural history and definition of pathological dilatation. We addressed fore-,...
9.
Markel M, Lacher M, Hall N, Martynov I, Siles Hinojosa A, de Augustin Asensio J, et al.
Br J Surg . 2023 Aug; 110(10):1397-1399. PMID: 37527435
No abstract available.
10.
Godbole N, Kyronlahti A, Hukkinen M, Pihlajoki M, Heikinheimo M, Pakarinen M
Acta Paediatr . 2023 Jun; 112(10):2210-2217. PMID: 37378619
Aim: The gut-liver axis may contribute to pathophysiology of cholestatic liver disorders like biliary atresia (BA) by bacterial translocation (BT). Toll-like receptors (TLR) are pattern recognition receptors known to activate...