Markku Heikinheimo
Overview
Explore the profile of Markku Heikinheimo including associated specialties, affiliations and a list of published articles.
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128
Citations
1793
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Recent Articles
1.
Langstrom S, Koskenvuo M, Huttunen P, Lassila R, Taskinen M, Ranta S, et al.
Clin Appl Thromb Hemost
. 2025 Feb;
31:10760296241304771.
PMID: 39905846
Aim: To evaluate the longitudinal coagulation profile after allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with hematological malignancies. Methods: Several coagulation variables were measured at predetermined time points...
2.
Nyholm I, Hukkinen M, Lohi J, Sjoblom N, Mutka A, Mutanen A, et al.
J Hepatol
. 2025 Jan;
PMID: 39889904
Background & Aims: Little is known on the mechanism of liver injury mediated by bile acids following Kasai portoenterostomy (KPE) in biliary atresia (BA). We sought to quantify individual serum...
3.
Pihlajoki M, Eloranta K, Nousiainen R, Vayrynen V, Soini T, Kyronlahti A, et al.
Adv Biol Regul
. 2024 Nov;
:100997.
PMID: 39492287
Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma...
4.
Nyholm I, Sjoblom N, Pihlajoki M, Hukkinen M, Lohi J, Heikkila P, et al.
Hepatol Commun
. 2023 Dec;
7(12).
PMID: 38051554
Background: We aimed to quantify ductular reaction (DR) in biliary atresia using a neural network in relation to underlying pathophysiology and prognosis. Methods: Image-processing neural network model was applied to...
5.
Godbole N, Kyronlahti A, Hukkinen M, Pihlajoki M, Heikinheimo M, Pakarinen M
Acta Paediatr
. 2023 Jun;
112(10):2210-2217.
PMID: 37378619
Aim: The gut-liver axis may contribute to pathophysiology of cholestatic liver disorders like biliary atresia (BA) by bacterial translocation (BT). Toll-like receptors (TLR) are pattern recognition receptors known to activate...
6.
Nousiainen R, Eloranta K, Isoaho N, Cairo S, Wilson D, Heikinheimo M, et al.
Front Genet
. 2023 Jun;
14:1170940.
PMID: 37377594
Hepatoblastoma (HB) is the most common malignant liver tumor among children. To gain insight into the pathobiology of HB, we performed RNA sequence analysis on 5 patient-derived xenograft lines (HB-243,...
7.
Eloranta K, Pihlajoki M, Liljestrom E, Nousiainen R, Soini T, Lohi J, et al.
Front Oncol
. 2023 Feb;
13:1118268.
PMID: 36776327
Background: In response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate...
8.
Nyholm I, Hukkinen M, Pihlajoki M, Davidson J, Tyraskis A, Lohi J, et al.
Hepatology
. 2023 Jan;
77(4):1263-1273.
PMID: 36692476
Background And Aims: Outcomes after Kasai portoenterostomy (KPE) for biliary atresia remain highly variable for unclear reasons. As reliable early biomarkers predicting KPE outcomes are lacking, we studied the prognostic...
9.
Andersson N, Haltia U, Farkkila A, Wong S, Eloranta K, Wilson D, et al.
Curr Issues Mol Biol
. 2022 Jun;
44(2):686-698.
PMID: 35723333
Adult-type granulosa cell tumor (AGCT) is a rare ovarian malignancy characterized by slow growth and hormonal activity. The prognosis of AGCT is generally favorable, but one-third of patients with low-stage...
10.
Godbole N, Nyholm I, Hukkinen M, Davidson J, Tyraskis A, Lohi J, et al.
Sci Rep
. 2022 May;
12(1):7233.
PMID: 35508528
Biliary atresia (BA) is a chronic neonatal cholangiopathy characterized by fibroinflammatory bile duct damage. Reliable biomarkers for predicting native liver survival (NLS) following portoenterostomy (PE) surgery are lacking. Herein we...