Maria C Heinz
Overview
Explore the profile of Maria C Heinz including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
312
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0
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Recent Articles
1.
Heinz M, Peters N, Oost K, Lindeboom R, van Voorthuijsen L, Fumagalli A, et al.
Cancer Res
. 2022 May;
82(10):1953-1968.
PMID: 35570706
Significance: Characterization of the cell type dynamics, composition, and transcriptome of early colorectal cancer liver metastases reveals that failure to establish cellular heterogeneity through YAP-controlled epithelial self-organization prohibits the outgrowth...
2.
Heinz M, Oost K, Snippert H
STAR Protoc
. 2020 Dec;
1(3):100126.
PMID: 33377020
Patient-derived organoids maintain functional and phenotypic characteristics of the original tissue such as cell-type diversity. Here, we provide protocols on how to label intestinal (cancer) stem cells by integrating the...
3.
Hageman J, Heinz M, Kretzschmar K, van der Vaart J, Clevers H, Snippert H
Dev Cell
. 2020 Aug;
54(4):435-446.
PMID: 32841594
Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through...
4.
Fumagalli A, Oost K, Kester L, Morgner J, Bornes L, Bruens L, et al.
Cell Stem Cell
. 2020 Mar;
26(4):569-578.e7.
PMID: 32169167
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal...
5.
Post Y, Puschhof J, Beumer J, Kerkkamp H, de Bakker M, Slagboom J, et al.
Cell
. 2020 Jan;
180(2):233-247.e21.
PMID: 31978343
Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features...
6.
Oost K, van Voorthuijsen L, Fumagalli A, Lindeboom R, Sprangers J, Omerzu M, et al.
Cell Rep
. 2018 Feb;
22(6):1600-1614.
PMID: 29425513
Organoid technology provides the possibility of culturing patient-derived colon tissue and colorectal cancers (CRCs) while maintaining all functional and phenotypic characteristics. Labeling stem cells, especially in normal and benign tumor...