Koen C Oost
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Explore the profile of Koen C Oost including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
818
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Recent Articles
1.
Kahnwald M, Mahlen M, Oost K, Liberali P
Nat Biotechnol
. 2024 Oct;
PMID: 39375447
No abstract available.
2.
Azkanaz M, Corominas-Murtra B, Ellenbroek S, Bruens L, Webb A, Laskaris D, et al.
Nature
. 2022 Jul;
607(7919):548-554.
PMID: 35831497
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts. Whether...
3.
Heinz M, Peters N, Oost K, Lindeboom R, van Voorthuijsen L, Fumagalli A, et al.
Cancer Res
. 2022 May;
82(10):1953-1968.
PMID: 35570706
Significance: Characterization of the cell type dynamics, composition, and transcriptome of early colorectal cancer liver metastases reveals that failure to establish cellular heterogeneity through YAP-controlled epithelial self-organization prohibits the outgrowth...
4.
Melhem H, Kaya B, Kaymak T, Wuggenig P, Flint E, Roux J, et al.
Mucosal Immunol
. 2022 Mar;
15(3):443-458.
PMID: 35264769
Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health. However, the molecular pathways that regulate goblet cell...
5.
Bollen Y, Stelloo E, van Leenen P, van den Bos M, Ponsioen B, Lu B, et al.
Nat Genet
. 2021 Jul;
53(8):1187-1195.
PMID: 34211178
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well...
6.
Heinz M, Oost K, Snippert H
STAR Protoc
. 2020 Dec;
1(3):100126.
PMID: 33377020
Patient-derived organoids maintain functional and phenotypic characteristics of the original tissue such as cell-type diversity. Here, we provide protocols on how to label intestinal (cancer) stem cells by integrating the...
7.
Fumagalli A, Oost K, Kester L, Morgner J, Bornes L, Bruens L, et al.
Cell Stem Cell
. 2020 Mar;
26(4):569-578.e7.
PMID: 32169167
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal...
8.
Yang Q, Oost K, Liberali P
Nat Cell Biol
. 2020 Mar;
22(3):261-263.
PMID: 32123334
No abstract available.
9.
Dekkers J, Alieva M, Wellens L, Ariese H, Jamieson P, Vonk A, et al.
Nat Protoc
. 2019 May;
14(6):1756-1771.
PMID: 31053799
In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the characterization of the cellular composition of organoids...
10.
Lindeboom R, van Voorthuijsen L, Oost K, Rodriguez-Colman M, Luna-Velez M, Furlan C, et al.
Mol Syst Biol
. 2018 Jun;
14(6):e8227.
PMID: 29945941
Intestinal organoids accurately recapitulate epithelial homeostasis , thereby representing a powerful system to investigate lineage specification and cellular differentiation. Here, we applied a multi-omics framework on stem cell-enriched and stem...