Lisa van Voorthuijsen
Overview
Explore the profile of Lisa van Voorthuijsen including associated specialties, affiliations and a list of published articles.
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8
Citations
381
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Recent Articles
1.
Heinz M, Peters N, Oost K, Lindeboom R, van Voorthuijsen L, Fumagalli A, et al.
Cancer Res
. 2022 May;
82(10):1953-1968.
PMID: 35570706
Significance: Characterization of the cell type dynamics, composition, and transcriptome of early colorectal cancer liver metastases reveals that failure to establish cellular heterogeneity through YAP-controlled epithelial self-organization prohibits the outgrowth...
2.
Wester R, van Voorthuijsen L, Neikes H, Dijkstra J, Lamers L, Frolich S, et al.
iScience
. 2021 Dec;
24(12):103444.
PMID: 34877501
Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA signaling is implicated in cancer initiation and progression. However, the mechanisms...
3.
de Wolf B, Oghabian A, Akinyi M, Hanks S, Tromer E, van Hooff J, et al.
EMBO J
. 2021 May;
40(14):e106536.
PMID: 34009673
Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely...
4.
Artegiani B, van Voorthuijsen L, Lindeboom R, Seinstra D, Heo I, Tapia P, et al.
Cell Stem Cell
. 2019 May;
24(6):927-943.e6.
PMID: 31130514
The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila homolog is known to deubiquitinate histone H2AK119. We...
5.
Kloet S, Karemaker I, van Voorthuijsen L, Lindeboom R, Baltissen M, Edupuganti R, et al.
Nat Commun
. 2018 Nov;
9(1):4588.
PMID: 30389936
The nucleosome remodeling and deacetylase (NuRD) complex plays an important role in gene expression regulation, stem cell self-renewal, and lineage commitment. However, little is known about the dynamics of NuRD...
6.
Lindeboom R, van Voorthuijsen L, Oost K, Rodriguez-Colman M, Luna-Velez M, Furlan C, et al.
Mol Syst Biol
. 2018 Jun;
14(6):e8227.
PMID: 29945941
Intestinal organoids accurately recapitulate epithelial homeostasis , thereby representing a powerful system to investigate lineage specification and cellular differentiation. Here, we applied a multi-omics framework on stem cell-enriched and stem...
7.
Oost K, van Voorthuijsen L, Fumagalli A, Lindeboom R, Sprangers J, Omerzu M, et al.
Cell Rep
. 2018 Feb;
22(6):1600-1614.
PMID: 29425513
Organoid technology provides the possibility of culturing patient-derived colon tissue and colorectal cancers (CRCs) while maintaining all functional and phenotypic characteristics. Labeling stem cells, especially in normal and benign tumor...
8.
Kloet S, Makowski M, Baymaz H, van Voorthuijsen L, Karemaker I, Santanach A, et al.
Nat Struct Mol Biol
. 2016 Jun;
23(7):682-690.
PMID: 27294783
Although the core subunits of Polycomb group (PcG) complexes are well characterized, little is known about the dynamics of these protein complexes during cellular differentiation. We used quantitative interaction proteomics...