Maria A W H van Waarde
Overview
Explore the profile of Maria A W H van Waarde including associated specialties, affiliations and a list of published articles.
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8
Citations
603
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Recent Articles
1.
Serlidaki D, van Waarde M, Rohland L, Wentink A, Dekker S, Kamphuis M, et al.
J Biol Chem
. 2020 Apr;
295(21):7301-7316.
PMID: 32284329
Heat shock protein 70 (HSP70) chaperones play a central role in protein quality control and are crucial for many cellular processes, including protein folding, degradation, and disaggregation. Human HSP70s compose...
2.
Meister-Broekema M, Freilich R, Jagadeesan C, Rauch J, Bengoechea R, Motley W, et al.
Nat Commun
. 2018 Dec;
9(1):5342.
PMID: 30559338
BAG3 is a multi-domain hub that connects two classes of chaperones, small heat shock proteins (sHSPs) via two isoleucine-proline-valine (IPV) motifs and Hsp70 via a BAG domain. Mutations in either...
3.
Kakkar V, Mansson C, de Mattos E, Bergink S, van der Zwaag M, van Waarde M, et al.
Mol Cell
. 2016 May;
62(2):272-283.
PMID: 27151442
Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show...
4.
Hageman J, van Waarde M, Zylicz A, Walerych D, Kampinga H
Biochem J
. 2011 Jan;
435(1):127-42.
PMID: 21231916
Humans contain many HSP (heat-shock protein) 70/HSPA- and HSP40/DNAJ-encoding genes and most of the corresponding proteins are localized in the cytosol. To test for possible functional differences and/or substrate specificity,...
5.
Hageman J, Rujano M, van Waarde M, Kakkar V, Dirks R, Govorukhina N, et al.
Mol Cell
. 2010 Feb;
37(3):355-69.
PMID: 20159555
Misfolding and aggregation are associated with cytotoxicity in several protein folding diseases. A large network of molecular chaperones ensures protein quality control. Here, we show that within the Hsp70, Hsp110,...
6.
Hageman J, Vos M, van Waarde M, Kampinga H
J Biol Chem
. 2007 Sep;
282(47):34334-45.
PMID: 17875648
Molecular chaperones are essential for cells to prevent that partially unfolded proteins form non-functional, toxic aggregates. This requirement is increased when cells experience protein unfolding stresses and such could affect...
7.
Rujano M, Bosveld F, Salomons F, Dijk F, van Waarde M, van der Want J, et al.
PLoS Biol
. 2006 Dec;
4(12):e417.
PMID: 17147470
Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes,...
8.
Hut H, Rembacz K, van Waarde M, Lemstra W, van Cappellen W, Kampinga H, et al.
Oncogene
. 2005 Oct;
24(51):7619-23.
PMID: 16205648
A remarkable and yet unexplained phenomenon in cancer cells is the presence of multiple centrosomes, organelles required for normal cell division. Previously, it was demonstrated that the tumor suppressor BRCA1...