Mari Aoki
Overview
Explore the profile of Mari Aoki including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
432
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Recent Articles
1.
Naganuma M, Kujirai T, Ehara H, Uejima T, Ito T, Goto M, et al.
Sci Adv
. 2025 Mar;
11(10):eadu0577.
PMID: 40043114
The metazoan transcription elongation complex (EC) of RNA polymerase II (RNAPII) generally stalls between the transcription start site and the first (+1) nucleosome. This promoter-proximal pausing involves negative elongation factor...
2.
Tanaka Y, Kumanogoh A, Atsumi T, Ishii T, Tago F, Aoki M, et al.
RMD Open
. 2024 Sep;
10(3).
PMID: 39289029
Objectives: To evaluate the safety, tolerability, pharmacokinetics (PK), biomarker response and efficacy of E6742 in a phase I/II study in patients with systemic lupus erythematosus (SLE). Methods: Two sequential cohorts...
3.
Yanagisawa T, Murayama Y, Ehara H, Goto M, Aoki M, Sekine S
Nat Commun
. 2024 Sep;
15(1):7854.
PMID: 39245712
The 5´-3´ exoribonuclease Rat1/Xrn2 is responsible for the termination of eukaryotic mRNA transcription by RNAPII. Rat1 forms a complex with its partner proteins, Rai1 and Rtt103, and acts as a...
4.
Tanaka Y, Tago F, Yamakawa N, Aoki M, Yagi T, Akira S
Immunol Med
. 2023 Sep;
47(1):24-29.
PMID: 37772762
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by inflammation in multiple organs. A few treatments for SLE currently exist, including antimalarials, glucocorticoids, immunosuppressants, and two recently approved antibody...
5.
Osawa T, Aoki M, Ehara H, Sekine S
Mol Cell
. 2023 Jul;
83(15):2781-2791.e4.
PMID: 37478848
Dengue is a mosquito-borne viral infection caused by dengue virus (DENV), a member of the flaviviruses. The DENV genome is a 5'-capped positive-sense RNA with a unique 5'-stem-loop structure (SLA),...
6.
Qiao S, Alasmi S, Wyatt A, Wartenberg P, Wang H, Candlish M, et al.
Nat Commun
. 2023 Feb;
14(1):1098.
PMID: 36841874
Inter-organ communication is a major hallmark of health and is often orchestrated by hormones released by the anterior pituitary gland. Pituitary gonadotropes secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH)...
7.
Murayama Y, Ehara H, Aoki M, Goto M, Yokoyama T, Sekine S
Sci Adv
. 2023 Feb;
9(6):eade7093.
PMID: 36753546
Transcription termination is an essential step in transcription by RNA polymerase (RNAP) and crucial for gene regulation. For many bacterial genes, transcription termination is mediated by the adenosine triphosphate-dependent RNA...
8.
Liu X, Aoki M, Osa S, Ito C, Saiki R, Nagai T, et al.
BMC Pharmacol Toxicol
. 2022 Dec;
23(1):89.
PMID: 36451204
Background: Linezolid causes hematological toxicity, mostly thrombocytopenia, which leads to treatment discontinuation and failure. Recent studies revealed that during linezolid therapy, the incidence of treatment-related hematological toxicity is significantly higher...
9.
Imasaki T, Kikkawa S, Niwa S, Saijo-Hamano Y, Shigematsu H, Aoyama K, et al.
Elife
. 2022 Jun;
11.
PMID: 35762204
Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin. Since a large energy barrier prevents microtubule nucleation in cells, the...
10.
Aoki M, Gamayun I, Wyatt A, Grunewald R, Simon-Thomas M, Philipp S, et al.
Sci Adv
. 2021 Oct;
7(41):eabg4074.
PMID: 34623921
Chemosensory cues detected in the nose need to be integrated with the hormonal status to trigger appropriate behaviors, but the neural circuits linking the olfactory and the endocrine system are...