Mari A Piirainen
Overview
Explore the profile of Mari A Piirainen including associated specialties, affiliations and a list of published articles.
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7
Citations
25
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0
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Recent Articles
1.
Piirainen M, Frey A
Front Mol Biosci
. 2022 Jun;
9:910709.
PMID: 35720120
Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market. The N-linked...
2.
Piirainen M, Salminen H, Frey A
Appl Microbiol Biotechnol
. 2021 Dec;
106(1):301-315.
PMID: 34910238
N-glycosylation is an important posttranslational modification affecting the properties and quality of therapeutic proteins. Glycoengineering in yeast aims to produce proteins carrying human-compatible glycosylation, enabling the production of therapeutic proteins...
3.
Koskela E, Gonzalez Salcedo A, Piirainen M, Iivonen H, Salminen H, Frey A
Front Bioeng Biotechnol
. 2020 Apr;
8:255.
PMID: 32296695
is a common platform for production of therapeutic proteins, but it is not intrinsically suited for the manufacturing of antibodies. Antibodies are naturally produced by plasma cells (PCs) and studies...
4.
Piirainen M, Frey A
FEMS Yeast Res
. 2020 Jan;
20(1).
PMID: 31922547
N-glycosylation plays an important role in the endoplasmic reticulum quality control (ERQC). N-glycan biosynthesis pathways have been engineered in yeasts and fungi to enable the production of therapeutic glycoproteins with...
5.
Piirainen M, Salminen H, Frey A
Methods Mol Biol
. 2019 Feb;
1923:227-241.
PMID: 30737743
The ability to control and adjust the N-glycosylation pathway of Saccharomyces cerevisiae is a key step toward production of therapeutic glycoproteins such as antibodies or erythropoietin. The focus of this...
6.
Piirainen M, Boer H, de Ruijter J, Frey A
Glycoconj J
. 2016 Mar;
33(2):189-99.
PMID: 26983412
N-glycosylation is an important feature of therapeutic and other industrially relevant proteins, and engineering of the N-glycosylation pathway provides opportunities for developing alternative, non-mammalian glycoprotein expression systems. Among yeasts, Saccharomyces...
7.
Piirainen M, de Ruijter J, Koskela E, Frey A
N Biotechnol
. 2014 Mar;
31(6):532-7.
PMID: 24632452
N-linked glycosylation of proteins is one of the most common posttranslational modifications. N-glycan structures and N-glycosylation efficiency are crucial parameters in the production of N-glycosylated proteins. Yeast cells can be...