Alexander D Frey
Overview
Explore the profile of Alexander D Frey including associated specialties, affiliations and a list of published articles.
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Articles
40
Citations
349
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Recent Articles
1.
Niemela L, Pasztor A, Frey A
Appl Microbiol Biotechnol
. 2025 Jan;
109(1):20.
PMID: 39847144
Metagenomes present a source for novel enzymes, but under 1% of environmental microbes are cultivatable. Because of its useful properties, Escherichia coli has been used as a host organism in...
2.
Nguyen A, Tunn I, Penttila M, Frey A
ACS Synth Biol
. 2025 Jan;
14(1):113-128.
PMID: 39757911
Often, the value of the whole biomass from fermentation processes is not exploited, as commercial interests are focused on the main product that is typically either accumulated within cells or...
3.
Niemela L, Koskela E, Frey A
J Biotechnol
. 2024 Mar;
387:1-11.
PMID: 38555020
The yeast Saccharomyces cerevisiae is a versatile cell factory used for manufacturing of a wide range of products, among them recombinant proteins. Protein folding is one of the rate-limiting processes...
4.
Piirainen M, Frey A
Front Mol Biosci
. 2022 Jun;
9:910709.
PMID: 35720120
Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market. The N-linked...
5.
Hokkanen S, Frey A, Yang B, Linderborg K
J Agric Food Chem
. 2022 May;
70(20):6191-6201.
PMID: 35543583
The similarity of the fat fraction in infant formulas rich in either bovine milk fat (MF) or vegetable oil (VO) to breast milk was evaluated by analyzing their lipid composition....
6.
Piirainen M, Salminen H, Frey A
Appl Microbiol Biotechnol
. 2021 Dec;
106(1):301-315.
PMID: 34910238
N-glycosylation is an important posttranslational modification affecting the properties and quality of therapeutic proteins. Glycoengineering in yeast aims to produce proteins carrying human-compatible glycosylation, enabling the production of therapeutic proteins...
7.
Usvalampi A, Li H, Frey A
Front Bioeng Biotechnol
. 2021 Jun;
9:678038.
PMID: 34150734
Glucose 6-phosphate is the phosphorylated form of glucose and is used as a reagent in enzymatic assays. Current production occurs via a multi-step chemical synthesis. In this study we established...
8.
Koskela E, Gonzalez Salcedo A, Piirainen M, Iivonen H, Salminen H, Frey A
Front Bioeng Biotechnol
. 2020 Apr;
8:255.
PMID: 32296695
is a common platform for production of therapeutic proteins, but it is not intrinsically suited for the manufacturing of antibodies. Antibodies are naturally produced by plasma cells (PCs) and studies...
9.
Piirainen M, Frey A
FEMS Yeast Res
. 2020 Jan;
20(1).
PMID: 31922547
N-glycosylation plays an important role in the endoplasmic reticulum quality control (ERQC). N-glycan biosynthesis pathways have been engineered in yeasts and fungi to enable the production of therapeutic glycoproteins with...
10.
Usvalampi A, Ruvalcaba Medrano M, Maaheimo H, Salminen H, Tossavainen O, Frey A
Glycoconj J
. 2019 Dec;
37(2):221-229.
PMID: 31792892
Fucosylated oligosaccharides are interesting molecules due to their bioactive properties. In particular, their application as active ingredient in milk powders is attractive for dairy industries. The objective of this study...