Margaret E Tome
Overview
Explore the profile of Margaret E Tome including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
35
Citations
629
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sarwar S, Tome M, Billheimer D, Spier C, Smith C, Persky D, et al.
Histol Histopathol
. 2023 Jun;
39(3):319-331.
PMID: 37377225
Since the approval of brentuximab vedotin (BV), assessment of CD30 status by immunohistochemistry gained increasing importance in the clinical management of patients diagnosed with CD30-expressing lymphomas, including classical Hodgkin lymphoma...
2.
Batinic-Haberle I, Tome M
Redox Biol
. 2019 May;
25:101139.
PMID: 31126869
Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins...
3.
Tome M, Jarvis C, Schaefer C, Jacobs L, Herndon J, Hunn K, et al.
J Cereb Blood Flow Metab
. 2018 Oct;
38(12):2209-2222.
PMID: 30346224
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity...
4.
Cottier K, Galloway E, Calabrese E, Tome M, Liktor-Busa E, Kim J, et al.
eNeuro
. 2018 Aug;
5(4).
PMID: 30073201
Cortical spreading depression (CSD) in the CNS is suggested as a common mechanism contributing to headache. Despite strong evidence for CNS involvement in headache disorders, drug development for headache disorders...
5.
Schaefer C, Arkwright N, Jacobs L, Jarvis C, Hunn K, Largent-Milnes T, et al.
PLoS One
. 2018 Feb;
13(2):e0192340.
PMID: 29414996
The rates of opioid prescription and use have continued to increase over the last few decades resulting in a greater number of opioid tolerant patients. Treatment of acute pain from...
6.
Tovmasyan A, Bueno-Janice J, Jaramillo M, Sampaio R, Reboucas J, Kyui N, et al.
Antioxid Redox Signal
. 2018 Feb;
29(13):1196-1214.
PMID: 29390861
Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing HO and...
7.
Schaefer C, Tome M, Davis T
Fluids Barriers CNS
. 2017 Nov;
14(1):32.
PMID: 29183383
Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use,...
8.
Tome M, Herndon J, Schaefer C, Jacobs L, Zhang Y, Jarvis C, et al.
J Cereb Blood Flow Metab
. 2016 Jul;
36(11):1913-1928.
PMID: 27466374
P-glycoprotein (PgP), a drug efflux pump in blood-brain barrier endothelial cells, is a major clinical obstacle for effective central nervous system drug delivery. Identifying PgP regulatory pathways that can be...
9.
Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al.
J Neurochem
. 2015 Apr;
134(2):200-10.
PMID: 25832806
Drug delivery to the brain for the treatment of pathologies with a CNS component is a significant clinical challenge. P-glycoprotein (PgP), a drug efflux pump in the endothelial cell membrane,...
10.
Jaramillo M, Briehl M, Batinic-Haberle I, Tome M
Free Radic Biol Med
. 2015 Mar;
83:89-100.
PMID: 25725417
The manganese porphyrin, manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin (MnTE-2-PyP(5+)), acts as a pro-oxidant in the presence of intracellular H2O2. Mitochondria are the most prominent source of intracellular ROS and important...